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    ASPGA1 N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830704, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ASPGA1
    Official Full Name
    N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein
    Primary source
    TAIR:AT5G08100
    Locus tag
    AT5G08100
    See related
    Araport:AT5G08100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    asparaginase A1; T22D6.40; T22D6_40
    Summary
    Encodes an asparaginase that catalyzes the degradation of L-asparagine to L-aspartic acid and ammonia.
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    Genomic context

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    See ASPGA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (2592976..2594701, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene syntaxin of plants 132 Neighboring gene uncharacterized protein Neighboring gene UBQ, helicase-c and DEAD-like helicase domain-containing protein Neighboring gene movement protein binding protein 2C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-occurrence of both L-asparaginase subtypes in Arabidopsis: At3g16150 encodes a K+-dependent L-asparaginase. Bruneau L, et al. Planta, 2006 Aug. PMID 16705405
    2. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_120892.4
    NM_203020.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables asparaginase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-aspartyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein
    NP_196427.1
    • N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein; CONTAINS InterPro DOMAIN/s: Peptidase T2, asparaginase 2 (InterPro:IPR000246); BEST Arabidopsis thaliana protein match is: N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein (TAIR:AT3G16150.1); Has 3243 Blast hits to 3196 proteins in 873 species: Archae - 113; Bacteria - 1502; Metazoa - 516; Fungi - 215; Plants - 193; Viruses - 0; Other Eukaryotes - 704 (source: NCBI BLink).
    NP_974749.1
    • N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein; CONTAINS InterPro DOMAIN/s: Peptidase T2, asparaginase 2 (InterPro:IPR000246); BEST Arabidopsis thaliana protein match is: N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein (TAIR:AT3G16150.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2592976..2594701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120892.4 → NP_196427.1  N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P50287, Q9LEZ6
      UniProtKB/TrEMBL
      A0A178UF74
      Conserved Domains (2) summary
      PRK10226
      Location:1 → 299
      PRK10226; isoaspartyl peptidase; Provisional
      PLN02689
      Location:1 → 313
      PLN02689; Bifunctional isoaspartyl peptidase/L-asparaginase

    2. NM_203020.2 → NP_974749.1  N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K9K7
      Conserved Domains (1) summary
      PLN02689
      Location:1 → 233
      PLN02689; Bifunctional isoaspartyl peptidase/L-asparaginase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50287.2

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