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    YAK1 YAK1-like protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833590, updated on 18-Sep-2024

    Summary

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    Official Symbol
    YAK1
    Official Full Name
    YAK1-like protein 1
    Primary source
    TAIR:AT5G35980
    Locus tag
    AT5G35980
    See related
    Araport:AT5G35980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MEE13.9; MEE13_9; yeast YAK1-related gene 1
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    Genomic context

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    See YAK1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Sequence:
    Chromosome: 5; NC_003076.8 (14127960..14136351)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene F-box/RNI-like superfamily protein Neighboring gene F-box protein RMF Neighboring gene ncRNA Neighboring gene RING/U-box superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations of the AtYAK1 Kinase Suppress TOR Deficiency in Arabidopsis. Forzani C, et al. Cell Rep, 2019 Jun 18. PMID 31216485
    2. Plant dual-specificity tyrosine phosphorylation-regulated kinase optimizes light-regulated growth and development in Arabidopsis. Huang WY, et al. Plant Cell Environ, 2017 Sep. PMID 28437590
    3. Arabidopsis YAK1 regulates abscisic acid response and drought resistance. Kim D, et al. FEBS Lett, 2016 Jul. PMID 27264339
    4. Arabidopsis Yak1 protein (AtYak1) is a dual specificity protein kinase. Kim D, et al. FEBS Lett, 2015 Oct 24. PMID 26452715
    5. A TOR-YAK1 signaling axis controls cell cycle, meristem activity and plant growth in Arabidopsis. Barrada A, et al. Development, 2019 Feb 7. PMID 30705074

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YAK1 is a major regulator of meristem activity and cell differentiation downstream of TOR.
      Title: A TOR-YAK1 signaling axis controls cell cycle, meristem activity and plant growth in Arabidopsis.
    2. AtYAK1 is an important regulator for various light responses, including the circadian clock, photomorphogenesis and reproductive development.
      Title: Plant dual-specificity tyrosine phosphorylation-regulated kinase optimizes light-regulated growth and development in Arabidopsis.
    3. these results indicate that AtYak1 plays a role as a positive regulator in ABA-mediated drought response in Arabidopsis.
      Title: Arabidopsis YAK1 regulates abscisic acid response and drought resistance.
    4. Results show that YAK1 is a dual specificity protein kinase in Arabidopsis that may regulate the phosphorylation status of serine/threonine or tyrosine residues of the annexin family proteins.
      Title: Arabidopsis Yak1 protein (AtYak1) is a dual specificity protein kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036893.2
    NM_001344125.1
    NM_122989.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    YAK1-like protein 1
    NP_001031970.1
    • yeast YAK1-related gene 1 (YAK1); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cytosol; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT3G17750.1); Has 91682 Blast hits to 90157 proteins in 2771 species: Archae - 99; Bacteria - 7981; Metazoa - 36897; Fungi - 11192; Plants - 18283; Viruses - 359; Other Eukaryotes - 16871 (source: NCBI BLink).
    NP_198447.2
    • yeast YAK1-related gene 1 (YAK1); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cytosol; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT3G17750.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      14127960..14136351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122989.4 → NP_198447.2  YAK1-like protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198447.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56YT6, Q8RWH3, Q9FGC1
      UniProtKB/TrEMBL
      A0A178UHZ7, A0A5S9Y9I9
      Conserved Domains (1) summary
      cd14212
      Location:122 → 464
      PKc_YAK1; Catalytic domain of the Dual-specificity protein kinase, YAK1

    2. NM_001036893.2 → NP_001031970.1  YAK1-like protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y9I9
      Conserved Domains (2) summary
      smart00220
      Location:122 → 464
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14212
      Location:122 → 464
      PKc_YAK1; Catalytic domain of the Dual-specificity protein kinase, YAK1

    3. NM_001344125.1 → NP_001332507.1  YAK1-like protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BH92, A0A5S9Y9I9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RWH3.1

    Gene LinkOut

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