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    GLA1 Folylpolyglutamate synthetase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834149, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLA1
    Official Full Name
    Folylpolyglutamate synthetase family protein
    Primary source
    TAIR:AT5G41480
    Locus tag
    AT5G41480
    See related
    Araport:AT5G41480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA DHFS-FPGS HOMOLOG A; ATDFA; DFA; DHFS-FPGS HOMOLOG A; EMB9; EMBRYO DEFECTIVE 9; GLOBULAR ARREST1; MYC6.18; MYC6_18
    Summary
    Encodes a dihydrofolate synthetase based on yeast complementation experiments. This protein is involved in folate biosynthesis.
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    Genomic context

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    See GLA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (16595863..16598682)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene transferring glycosyl group transferase (DUF604) Neighboring gene Nuclear transport factor 2 (NTF2) family protein Neighboring gene ncRNA Neighboring gene F-box associated ubiquitination effector family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The GLOBULAR ARREST1 gene, which is involved in the biosynthesis of folates, is essential for embryogenesis in Arabidopsis thaliana. Ishikawa T, et al. Plant J, 2003 Jan. PMID 12535338
    2. Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana. Ravanel S, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11752472, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_123512.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dihydrofolate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables tetrahydrofolylpolyglutamate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within one-carbon metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Folylpolyglutamate synthetase family protein
    NP_198963.2
    • GLOBULAR ARREST1 (GLA1); FUNCTIONS IN: dihydrofolate synthase activity; INVOLVED IN: one-carbon metabolic process, embryo development ending in seed dormancy; LOCATED IN: mitochondrial matrix; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mur ligase, central (InterPro:IPR013221), Folylpolyglutamate synthetase, conserved site (InterPro:IPR018109), Mur ligase, C-terminal (InterPro:IPR004101), Folylpolyglutamate synthetase (InterPro:IPR001645); BEST Arabidopsis thaliana protein match is: DHFS-FPGS homolog B (TAIR:AT5G05980.2); Has 8245 Blast hits to 8243 proteins in 2505 species: Archae - 47; Bacteria - 5105; Metazoa - 156; Fungi - 354; Plants - 131; Viruses - 0; Other Eukaryotes - 2452 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16595863..16598682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123512.3 → NP_198963.2  Folylpolyglutamate synthetase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198963.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JYE9, Q7Y203, Q8W041, Q9FN53
      UniProtKB/TrEMBL
      A0A654G740
      Conserved Domains (3) summary
      PLN02913
      Location:20 → 530
      PLN02913; dihydrofolate synthetase
      pfam02875
      Location:389 → 451
      Mur_ligase_C; Mur ligase family, glutamate ligase domain
      pfam08245
      Location:183 → 248
      Mur_ligase_M; Mur ligase middle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JYE9.1

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