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    XRCC3 homolog of X-ray repair cross complementing 3 (XRCC3) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835850, updated on 18-Sep-2024

    Summary

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    Official Symbol
    XRCC3
    Official Full Name
    homolog of X-ray repair cross complementing 3 (XRCC3)
    Primary source
    TAIR:AT5G57450
    Locus tag
    AT5G57450
    See related
    Araport:AT5G57450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA HOMOLOG OF X-RAY REPAIR CROSS COMPLEMENTING 3 (XRCC3); ATXRCC3; homolog of X-ray repair cross complementing 3; homolog of X-ray repair cross complementing 3 (XRCC3); MUA2.3; MUA2_3
    Summary
    Involved in homologous recombination and recombinational repair, mutants are sterile, hypersensitive to DNA crosslinking agents, show aberrant meiosis with extensive chromosome fragmentation
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    Genomic context

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    See XRCC3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (23273067..23274976, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene indole-3-acetic acid inducible 33 Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene muniscin carboxy-terminal mu-like domain protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis homologue of Xrcc3 plays an essential role in meiosis. Bleuyard JY, et al. EMBO J, 2004 Jan 28. PMID 14726957, Free PMC Article
    2. Molecular cloning and characterization of RAD51-like genes from Arabidopsis thaliana. Osakabe K, et al. Plant Mol Biol, 2002 Sep. PMID 12139010
    3. The requirement for recombination factors differs considerably between different pathways of homologous double-strand break repair in somatic plant cells. Roth N, et al. Plant J, 2012 Dec. PMID 22860689
    4. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125127.3
    NM_180871.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via synthesis-dependent strand annealing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homolog of X-ray repair cross complementing 3 (XRCC3)
    NP_200554.1
    • homolog of X-ray repair cross complementing 3 (XRCC3) (XRCC3); CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: RAS associated with diabetes protein 51C (TAIR:AT2G45280.1); Has 2317 Blast hits to 2308 proteins in 507 species: Archae - 430; Bacteria - 4; Metazoa - 689; Fungi - 429; Plants - 393; Viruses - 0; Other Eukaryotes - 372 (source: NCBI BLink).
    NP_851202.1
    • homolog of X-ray repair cross complementing 3 (XRCC3) (XRCC3); CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: RAS associated with diabetes protein 51C (TAIR:AT2G45280.1); Has 2320 Blast hits to 2311 proteins in 507 species: Archae - 432; Bacteria - 4; Metazoa - 689; Fungi - 430; Plants - 393; Viruses - 0; Other Eukaryotes - 372 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23273067..23274976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180871.2 → NP_851202.1  homolog of X-ray repair cross complementing 3 (XRCC3) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FKM5
      UniProtKB/TrEMBL
      A0A178UTR8, A0A5S9YEW7, Q147M1
      Conserved Domains (1) summary
      cd19491
      Location:28 → 286
      XRCC3; XRCC3 recombinase

    2. NM_125127.3 → NP_200554.1  homolog of X-ray repair cross complementing 3 (XRCC3) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FKM5
      UniProtKB/TrEMBL
      A0A178UTR8, A0A5S9YEW7, Q147M1
      Conserved Domains (1) summary
      cd19491
      Location:28 → 286
      XRCC3; XRCC3 recombinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FKM5.1

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