emb2411 DNA replication helicase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: emb2411
Official Full Name: DNA replication helicase
Primary source: TAIR:AT1G08840
Locus tag: AT1G08840
See related: Araport:AT1G08840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: embryo defective 2411
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Genomic context

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See emb2411 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 37

Sequence:: Chromosome: 1; NC_003070.9 (2829105..2838855, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

At1g08840 plays an important role in DNA replication and damage repair, meristem maintenance, and development.
Title: A DNA2 Homolog Is Required for DNA Damage Repair, Cell Cycle Regulation, and Meristem Maintenance in Plants.

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables single-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	NAS Non-traceable Author Statement more info
acts_upstream_of_or_within meristem maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meristem maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: DNA replication helicase

NP_001184943.1

embryo defective 2411 (emb2411); FUNCTIONS IN: ATP-dependent DNA helicase activity, DNA binding, ATP binding; INVOLVED IN: DNA replication, embryo development ending in seed dormancy; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA helicase, UvrD/REP type (InterPro:IPR000212), DNA replication factor Dna2 (InterPro:IPR014808); BEST Arabidopsis thaliana protein match is: DNA-binding protein, putative (TAIR:AT2G03270.1).

NP_001318959.1

embryo defective 2411 (emb2411); FUNCTIONS IN: ATP-dependent DNA helicase activity, DNA binding, ATP binding; INVOLVED IN: DNA replication, embryo development ending in seed dormancy; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA helicase, UvrD/REP type (InterPro:IPR000212), DNA replication factor Dna2 (InterPro:IPR014808); BEST Arabidopsis thaliana protein match is: DNA-binding protein, putative (TAIR:AT2G03270.1); Has 6121 Blast hits to 5421 proteins in 1016 species: Archae - 240; Bacteria - 1986; Metazoa - 1238; Fungi - 1140; Plants - 545; Viruses - 30; Other Eukaryotes - 942 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

2829105..2838855 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001198014.1 → NP_001184943.1 DNA replication helicase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001184943.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654E863

Conserved Domains (5) summary

pfam08696
Location:340 → 543

Dna2; DNA replication factor Dna2

pfam13086
Location:907 → 1075

AAA_11; AAA domain

pfam13087
Location:1082 → 1282

AAA_12; AAA domain

cl00641
Location:490 → 660

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:906 → 1098

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001331794.1 → NP_001318959.1 DNA replication helicase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A654E863, F4HXR5
NM_001331796.1 → NP_001322073.1 DNA replication helicase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WK35, A0A5S9TCQ8

Conserved Domains (3) summary

TIGR00376
Location:798 → 1314

TIGR00376; DNA helicase, putative

cd18041
Location:919 → 1119

DEXXQc_DNA2; DEXXQ-box helicase domain of DNA2

cd22318
Location:410 → 644

DNA2_N-like; Nuclease domain of the nuclease/helicase DNA2 and related nucleases
NM_001331795.1 → NP_001322072.1 DNA replication helicase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1P8ASV1, A0A1P8ASY1, F4HXR6, O04043, O04044

UniProtKB/TrEMBL

A0A7G2DRQ4

Conserved Domains (4) summary

TIGR00376
Location:801 → 1317

TIGR00376; DNA helicase, putative

cd18041
Location:922 → 1122

DEXXQc_DNA2; DEXXQ-box helicase domain of DNA2

pfam08696
Location:356 → 559

Dna2; DNA replication factor Dna2

cl00641
Location:506 → 676

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
NM_001331797.1 → NP_001322071.1 DNA replication helicase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8ASU0