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    PDS1 4-hydroxyphenylpyruvate dioxygenase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837168, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDS1
    Official Full Name
    4-hydroxyphenylpyruvate dioxygenase
    Primary source
    TAIR:AT1G06570
    Locus tag
    AT1G06570
    See related
    Araport:AT1G06570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4-hydroxyphenylpyruvate dioxygenase; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; F12K11.9; F12K11_9; HPD; HPPD; P-HYDROXYPHENYLPYRUVATE DIOXYGENASE; phytoene desaturation 1
    Summary
    Mutation of the PDS1 locus disrupts the activity of p-hydroxyphenylpyruvate dioxygenase (HPPDase), the first committed step in the synthesis of both plastoquinone and tocopherols in plants.
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    Genomic context

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    See PDS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (2011885..2013545, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ATP-dependent caseinolytic (Clp) protease/crotonase family protein Neighboring gene NOL1/NOP2/sun family protein Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene anaphase-promoting complex subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase. Fritze IM, et al. Plant Physiol, 2004 Apr. PMID 15084729, Free PMC Article
    2. Characterization and subcellular compartmentation of recombinant 4-hydroxyphenylpyruvate dioxygenase from Arabidopsis in transgenic tobacco. Garcia I, et al. Plant Physiol, 1999 Apr. PMID 10198110, Free PMC Article
    3. Complementation of the Arabidopsis pds1 mutation with the gene encoding p-hydroxyphenylpyruvate dioxygenase. Norris SR, et al. Plant Physiol, 1998 Aug. PMID 9701587, Free PMC Article
    4. Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases. Yang C, et al. Biochemistry, 2004 Aug 17. PMID 15301540
    5. Genetic dissection of carotenoid synthesis in arabidopsis defines plastoquinone as an essential component of phytoene desaturation. Norris SR, et al. Plant Cell, 1995 Dec. PMID 8718624, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001160839.1
    NM_100536.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-hydroxyphenylpyruvate dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-hydroxyphenylpyruvate dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carotenoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plastoquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vitamin E biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    4-hydroxyphenylpyruvate dioxygenase
    NP_001154311.1
    • phytoene desaturation 1 (PDS1); CONTAINS InterPro DOMAIN/s: 4-hydroxyphenylpyruvate dioxygenase (InterPro:IPR005956), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); Has 2393 Blast hits to 2392 proteins in 824 species: Archae - 3; Bacteria - 1672; Metazoa - 205; Fungi - 157; Plants - 91; Viruses - 0; Other Eukaryotes - 265 (source: NCBI BLink).
    NP_172144.3
    • phytoene desaturation 1 (PDS1); CONTAINS InterPro DOMAIN/s: 4-hydroxyphenylpyruvate dioxygenase (InterPro:IPR005956), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); Has 2414 Blast hits to 2412 proteins in 817 species: Archae - 3; Bacteria - 1671; Metazoa - 206; Fungi - 158; Plants - 88; Viruses - 0; Other Eukaryotes - 288 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2011885..2013545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001160839.1 → NP_001154311.1  4-hydroxyphenylpyruvate dioxygenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154311.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHQ7, F4IDP2
      Conserved Domains (3) summary
      cd07250
      Location:249 → 416
      HPPD_C_like; C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS)
      cd08342
      Location:75 → 235
      HPPD_N_like; N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS)
      PLN02875
      Location:75 → 416
      PLN02875; 4-hydroxyphenylpyruvate dioxygenase

    2. NM_100536.4 → NP_172144.3  4-hydroxyphenylpyruvate dioxygenase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IDP1, O04330, P93836, Q9SHK1
      UniProtKB/TrEMBL
      A0A178WHQ7, A0A5S9SZ06, A0A654E7B4
      Conserved Domains (1) summary
      PLN02875
      Location:47 → 440
      PLN02875; 4-hydroxyphenylpyruvate dioxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P93836.2

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