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    HEI10 RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841784, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEI10
    Official Full Name
    RING/U-box superfamily protein
    Primary source
    TAIR:AT1G53490
    Locus tag
    AT1G53490
    See related
    Araport:AT1G53490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22G10.16; homolog of human HEI10 ( Enhancer of cell Invasion No.10)
    Summary
    Encodes HEI10, a RING finger-containing protein. HEI10 belongs to a group of proteins well conserved among species known as ZMM. Required for class I crossover formation.
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    Genomic context

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    See HEI10 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (19963267..19966952)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene craniofacial development protein Neighboring gene mechanosensitive channel of small conductance-like 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mto 1 responding down 1 Neighboring gene ncRNA Neighboring gene NAD-dependent epimerase/dehydratase family protein Neighboring gene mitogen-activated protein kinase 18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis. Morgan C, et al. Nat Commun, 2021 Aug 3. PMID 34344879, Free PMC Article
    2. HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation. Wang T, et al. Proc Natl Acad Sci U S A, 2023 Dec 26. PMID 38134200, Free PMC Article
    3. The Arabidopsis HEI10 is a new ZMM protein related to Zip3. Chelysheva L, et al. PLoS Genet, 2012. PMID 22844245, Free PMC Article
    4. The role of rice HEI10 in the formation of meiotic crossovers. Wang K, et al. PLoS Genet, 2012 Jul. PMID 22792078, Free PMC Article
    5. FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia factors, limit meiotic crossovers. Girard C, et al. Nucleic Acids Res, 2014 Aug. PMID 25038251, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.
      Title: HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.
    2. Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis.
      Title: Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis.
    3. HEI10 protein is present as numerous foci on chromosome axes during early meiotic prophase and is retained until the end of prophase at a limited number of sites corresponding to crossovers. HEI10 is structurally and functionally related to the yeast Zip3 ZMM and that it is absolutely required for class I crossover formation in Arabidopsis thaliana. [HEI10]
      Title: The Arabidopsis HEI10 is a new ZMM protein related to Zip3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001333596.1
    NM_104227.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chiasma assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chiasma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING/U-box superfamily protein
    NP_175754.2
    • RING/U-box superfamily protein; Has 175 Blast hits to 173 proteins in 83 species: Archae - 2; Bacteria - 14; Metazoa - 69; Fungi - 24; Plants - 38; Viruses - 0; Other Eukaryotes - 28 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19963267..19966952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104227.2 → NP_175754.2  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175754.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HRI2, Q9C8L1, Q9LPG5
      UniProtKB/TrEMBL
      A0A178W8Z0
      Conserved Domains (2) summary
      pfam10158
      Location:106 → 173
      LOH1CR12; Tumour suppressor protein
      pfam14634
      Location:2 → 43
      zf-RING_5; zinc-RING finger domain

    2. NM_001333596.1 → NP_001321879.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W7F3, A0A1P8AS84
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HRI2.1

    Gene LinkOut

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