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    SPPL2 SIGNAL PEPTIDE PEPTIDASE-LIKE 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842673, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPPL2
    Official Full Name
    SIGNAL PEPTIDE PEPTIDASE-LIKE 2
    Primary source
    TAIR:AT1G63690
    Locus tag
    AT1G63690
    See related
    Araport:AT1G63690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSPPL2; F24D7.12; F24D7_12; SIGNAL PEPTIDE PEPTIDASE-LIKE 2
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    Genomic context

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    See SPPL2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (23618012..23622396)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF3741) Neighboring gene ALBINO OR PALE-GREEN 13 Neighboring gene Protein kinase superfamily protein Neighboring gene cytochrome P450, family 86, subfamily A, polypeptide 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signal peptide peptidase and its homologs in Arabidopsis thaliana--plant tissue-specific expression and distinct subcellular localization. Tamura T, et al. FEBS J, 2008 Jan. PMID 18067581
    2. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105046.3
    NM_202353.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SIGNAL PEPTIDE PEPTIDASE-LIKE 2
    NP_564815.1
    • SIGNAL PEPTIDE PEPTIDASE-LIKE 2 (SPPL2); FUNCTIONS IN: peptidase activity, aspartic-type endopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: endosome, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protease-associated PA (InterPro:IPR003137), Peptidase A22, presenilin signal peptide (InterPro:IPR006639), Peptidase A22B, signal peptide peptidase (InterPro:IPR007369); BEST Arabidopsis thaliana protein match is: SIGNAL PEPTIDE PEPTIDASE-LIKE 4 (TAIR:AT1G01650.1); Has 1779 Blast hits to 1755 proteins in 292 species: Archae - 1; Bacteria - 179; Metazoa - 755; Fungi - 159; Plants - 440; Viruses - 0; Other Eukaryotes - 245 (source: NCBI BLink).
    NP_974082.1
    • SIGNAL PEPTIDE PEPTIDASE-LIKE 2 (SPPL2); FUNCTIONS IN: peptidase activity, aspartic-type endopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: endosome, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protease-associated PA (InterPro:IPR003137), Peptidase A22, presenilin signal peptide (InterPro:IPR006639), Peptidase A22B, signal peptide peptidase (InterPro:IPR007369); BEST Arabidopsis thaliana protein match is: SIGNAL PEPTIDE PEPTIDASE-LIKE 4 (TAIR:AT1G01650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23618012..23622396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105046.3 → NP_564815.1  SIGNAL PEPTIDE PEPTIDASE-LIKE 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564815.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LCK4, Q8W469, Q9CAD4
      UniProtKB/TrEMBL
      A0A178WA20, A0A5S9WS38
      Conserved Domains (2) summary
      cd02132
      Location:46 → 184
      PA_GO-like; PA_GO-like: Protease-associated domain containing proteins like Arabidopsis thaliana growth-on protein GRO10. This group contains various PA domain-containing proteins similar to the functionally uncharacterized Arabidopsis GRO10. The PA domain may be a ...
      pfam04258
      Location:245 → 525
      Peptidase_A22B; Signal peptide peptidase

    2. NM_202353.1 → NP_974082.1  SIGNAL PEPTIDE PEPTIDASE-LIKE 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974082.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WA20, A0A5S9WS38, F4I3Q0
      Conserved Domains (2) summary
      cd02132
      Location:46 → 184
      PA_GO-like; PA_GO-like: Protease-associated domain containing proteins like Arabidopsis thaliana growth-on protein GRO10. This group contains various PA domain-containing proteins similar to the functionally uncharacterized Arabidopsis GRO10. The PA domain may be a ...
      pfam04258
      Location:245 → 525
      Peptidase_A22B; Signal peptide peptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W469.1

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