BIG auxin transport protein (BIG) [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: BIG
Official Full Name: auxin transport protein (BIG)
Primary source: TAIR:AT3G02260
Locus tag: AT3G02260
See related: Araport:AT3G02260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ASA1; ATTENUATED SHADE AVOIDANCE 1; CORYMBOSA1; CRM1; DARK OVER-EXPRESSION OF CAB 1; DOC1; F14P3.3; F14P3_3; LOW PHOSPHATE-RESISTANT ROOT 1; LPR1; TIR3; TRANSPORT INHIBITOR RESPONSE 3; UMB1; UMBRELLA 1
Summary: Calossin-like protein required for polar auxin transport
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See BIG in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 14

Sequence:: Chromosome: 3; NC_003074.8 (430877..448680, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of Arabidopsis BIG protein in cell death mediated by Myo-inositol homeostasis.
Title: Involvement of Arabidopsis BIG protein in cell death mediated by Myo-inositol homeostasis.
The BIG gene controls size of shoot apical meristems in Arabidopsis thaliana.
Title: The BIG gene controls size of shoot apical meristems in Arabidopsis thaliana.
BIG connects nutrient, light, and hormone signaling networks for regulating plant development and adaptive responses.
Title: BIG regulates sugar response and C/N balance in Arabidopsis.
BIG warrants recognition as a new and distinct regulator that regulates jasmonic acid responses.
Title: BIG regulates stomatal immunity and jasmonate production in Arabidopsis.
In the control of stomatal aperture by carbon dioxide (CO2) , BIG is only required in elevated CO2 -induced closure and not in the inhibition of stomatal opening by this environmental signal.
Title: The BIG protein distinguishes the process of CO(2) -induced stomatal closure from the inhibition of stomatal opening by CO(2).
Data indicate that auxin transport protein (BIG) is a regulator of the dynamic adjustment of circadian period and phase.
Title: BIG Regulates Dynamic Adjustment of Circadian Period in Arabidopsis thaliana.
The crm1 mutants had defects in cell division and elongation. Auxin signaling and cell cycle gene expression in crm1 inflorescences were lower than those in the wild type ...mutants defective in auxin signaling had shorter pedicels and internodes...
Title: The role of CORYMBOSA1/BIG and auxin in the growth of Arabidopsis pedicel and internode.
required for organ growth via auxin action
Title: The BIG gene is required for auxin-mediated organ growth in Arabidopsis.
results suggest that CRM1/BIG controls the elongation of the pedicels and stem internodes through auxin action
Title: CRM1/BIG-mediated auxin action regulates Arabidopsis inflorescence development.
BIG is required for pericycle cell activation to form LRP in both high and low phosphate conditions, but not for the low P-induced alterations in primary root growth, lateral root emergence, and root hair elongation.
Title: An auxin transport independent pathway is involved in phosphate stress-induced root architectural alterations in Arabidopsis. Identification of BIG as a mediator of auxin in pericycle cell activation.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_111093.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within auxin polar transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within indeterminate inflorescence morphogenesis	IMP Inferred from Mutant Phenotype more info
involved_in inflorescence morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral root formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photomorphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: auxin transport protein (BIG)

NP_186875.2

BIG (BIG); FUNCTIONS IN: ubiquitin-protein ligase activity, binding, zinc ion binding; INVOLVED IN: response to auxin stimulus, indeterminate inflorescence morphogenesis, photomorphogenesis, root development, auxin polar transport; LOCATED IN: membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), Zinc finger, N-recognin, metazoa (InterPro:IPR013993), Armadillo-type fold (InterPro:IPR016024), Zinc finger, ZZ-type (InterPro:IPR000433), Zinc finger, N-recognin (InterPro:IPR003126); Has 1182 Blast hits to 997 proteins in 123 species: Archae - 0; Bacteria - 4; Metazoa - 768; Fungi - 44; Plants - 189; Viruses - 0; Other Eukaryotes - 177 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

430877..448680 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001337388.1 → NP_001327521.1 auxin transport protein (BIG) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LSK4, A0A654F3E8
NM_001337389.1 → NP_001327522.1 auxin transport protein (BIG) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LSK5, A0A654F3E8
NM_001337390.1 → NP_001327520.1 auxin transport protein (BIG) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LSK3, A0A654F3E8
NM_111093.2 → NP_186875.2 auxin transport protein (BIG) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_186875.2

Status: REVIEWED

UniProtKB/Swiss-Prot

F4J4S0, Q9SRU2

UniProtKB/TrEMBL

A0A654F3E8

Conserved Domains (3) summary

smart00396
Location:1573 → 1641

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

cd02249
Location:2616 → 2667

ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

pfam13764
Location:4177 → 5074

E3_UbLigase_R4; E3 ubiquitin-protein ligase UBR4