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    MBF1C multiprotein bridging factor 1C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822041, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MBF1C
    Official Full Name
    multiprotein bridging factor 1C
    Primary source
    TAIR:AT3G24500
    Locus tag
    AT3G24500
    See related
    Araport:AT3G24500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMBF1C; MOB24.13; multiprotein bridging factor 1C
    Summary
    One of three genes in A. thaliana encoding multiprotein bridging factor 1, a highly conserved transcriptional coactivator. May serve as a bridging factor between a bZIP factor and TBP. Its expression is specifically elevated in response to pathogen infection, salinity, drought, heat, hydrogen peroxide, and application of abscisic acid or salicylic acid. Constitutive expression enhances the tolerance of transgenic plants to various biotic and abiotic stresses.
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    Genomic context

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    See MBF1C in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (8918267..8919683)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene Alcohol dehydrogenase transcription factor Myb/SANT-like family protein Neighboring gene MUTS homolog 7 Neighboring gene ncRNA Neighboring gene aldehyde dehydrogenase 2C4 Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the MBF1 heat-response regulon of Arabidopsis thaliana. Suzuki N, et al. Plant J, 2011 Jun. PMID 21457365, Free PMC Article
    2. Enhanced tolerance to environmental stress in transgenic plants expressing the transcriptional coactivator multiprotein bridging factor 1c. Suzuki N, et al. Plant Physiol, 2005 Nov. PMID 16244138, Free PMC Article
    3. Structure and expression analysis of three subtypes of Arabidopsis MBF1 genes. Tsuda K, et al. Biochim Biophys Acta, 2004 Oct 5. PMID 15451167
    4. The transcriptional co-activator MBF1c is a key regulator of thermotolerance in Arabidopsis thaliana. Suzuki N, et al. J Biol Chem, 2008 Apr 4. PMID 18201973
    5. The analysis of an Arabidopsis triple knock-down mutant reveals functions for MBF1 genes under oxidative stress conditions. Arce DP, et al. J Plant Physiol, 2010 Feb 15. PMID 19783066

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MBF1c functions as a transcriptional regulator which binds DNA and controls the expression of 36 different transcripts during heat stress, including the DRE-binding protein 2A, two heat shock transcription factors, and several zinc finger proteins.
      Title: Identification of the MBF1 heat-response regulon of Arabidopsis thaliana.
    2. possible negative regulator of HSP genes; triple knock-down mutant for MBF1a, MBF1b andtMBF1c sensitive to oxidative stress and osmotic stress
      Title: The analysis of an Arabidopsis triple knock-down mutant reveals functions for MBF1 genes under oxidative stress conditions.
    3. the existence of a tightly coordinated heat stress-response network, involving trehalose-, SA-, and ethylene-signaling pathways, that is under the control of MBF1c.
      Title: The transcriptional co-activator MBF1c is a key regulator of thermotolerance in Arabidopsis thaliana.
    4. constitutive expression of MBF1c enhances the tolerance of transgenic plants to bacterial infection, heat and osmotic stress by perturbing the ethylene-response signal transduction pathway. [Multiprotein bridging factor1 protein] [MBF1c]
      Title: Enhanced tolerance to environmental stress in transgenic plants expressing the transcriptional coactivator multiprotein bridging factor 1c.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203033.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transcription coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within ethylene-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular anatomical structure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    multiprotein bridging factor 1C
    NP_001189962.1
    • multiprotein bridging factor 1C (MBF1C); FUNCTIONS IN: transcription coactivator activity, DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; LOCATED IN: nucleolus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Multiprotein bridging factor 1, N-terminal (InterPro:IPR013729); BEST Arabidopsis thaliana protein match is: multiprotein bridging factor 1B (TAIR:AT3G58680.1).
    NP_189093.1
    • multiprotein bridging factor 1C (MBF1C); CONTAINS InterPro DOMAIN/s: Lambda repressor-like, DNA-binding (InterPro:IPR010982), Multiprotein bridging factor 1, N-terminal (InterPro:IPR013729), Helix-turn-helix type 3 (InterPro:IPR001387); BEST Arabidopsis thaliana protein match is: multiprotein bridging factor 1B (TAIR:AT3G58680.1); Has 715 Blast hits to 715 proteins in 278 species: Archae - 65; Bacteria - 30; Metazoa - 196; Fungi - 149; Plants - 136; Viruses - 2; Other Eukaryotes - 137 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8918267..8919683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113358.3 → NP_189093.1  multiprotein bridging factor 1C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LE67, Q9LV58
      UniProtKB/TrEMBL
      A0A178VDH9, A0A5S9XFD2
      Conserved Domains (2) summary
      smart00530
      Location:90 → 143
      HTH_XRE; Helix-turn-helix XRE-family like proteins
      pfam08523
      Location:12 → 81
      MBF1; Multiprotein bridging factor 1

    2. NM_001203033.1 → NP_001189962.1  multiprotein bridging factor 1C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4J6M0
      Conserved Domains (1) summary
      pfam08523
      Location:11 → 82
      MBF1; Multiprotein bridging factor 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LV58.1

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