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    XLG2 extra-large GTP-binding protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829589, updated on 18-Sep-2024

    Summary

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    Official Symbol
    XLG2
    Official Full Name
    extra-large GTP-binding protein 2
    Primary source
    TAIR:AT4G34390
    Locus tag
    AT4G34390
    See related
    Araport:AT4G34390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    extra-large GTP-binding protein 2; F10M10.160; F10M10_160
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    Genomic context

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    See XLG2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (16441086..16445017)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GTP binding by Arabidopsis extra-large G protein 2 is not essential for its functions. Maruta N, et al. Plant Physiol, 2021 Jun 11. PMID 33729516, Free PMC Article
    2. XLG2 and CORI3 function additively to regulate plant defense against the necrotrophic pathogen Sclerotinia sclerotiorum. Tiwari R, et al. Plant J, 2024 Jan. PMID 37910396
    3. EXTRA LARGE G-PROTEIN2 mediates cell death and hyperimmunity in the chitin elicitor receptor kinase 1-4 mutant. Petutschnig E, et al. Plant Physiol, 2022 Aug 1. PMID 35522044, Free PMC Article
    4. Arabidopsis extra large G-protein 2 (XLG2) interacts with the Gbeta subunit of heterotrimeric G protein and functions in disease resistance. Zhu H, et al. Mol Plant, 2009 May. PMID 19825634, Free PMC Article
    5. Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity. Wang Y, et al. J Integr Plant Biol, 2023 Mar. PMID 36250681

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. XLG2 and CORI3 function additively to regulate plant defense against the necrotrophic pathogen Sclerotinia sclerotiorum.
      Title: XLG2 and CORI3 function additively to regulate plant defense against the necrotrophic pathogen Sclerotinia sclerotiorum.
    2. Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity.
      Title: Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity.
    3. GTP binding by Arabidopsis extra-large G protein 2 is not essential for its functions.
      Title: GTP binding by Arabidopsis extra-large G protein 2 is not essential for its functions.
    4. XLG2 interaction with PUB4 and PUB2
      Title: EXTRA-LARGE G PROTEINs Interact with E3 Ligases PUB4 and PUB2 and Function in Cytokinin and Developmental Processes.
    5. XLGs can bind Gbetagamma dimers.
      Title: Extra-Large G Proteins Expand the Repertoire of Subunits in Arabidopsis Heterotrimeric G Protein Signaling.
    6. a Ca(2+)-dependent G protein, XLG2, promotes RTV1 DNA binding activity for a subset of floral integrator genes and contributes to floral transition.
      Title: Ca2+-dependent GTPase, extra-large G protein 2 (XLG2), promotes activation of DNA-binding protein related to vernalization 1 (RTV1), leading to activation of floral integrator genes and early flowering in Arabidopsis.
    7. study describes initial functional characterization of XLG1, XLG2 & XZLG3 genes & reveals a role for XLG proteins in the regulation of root growth and seed germination by sugars and phytohormones
      Title: Arabidopsis extra-large G proteins (XLGs) regulate root morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001342282.1
    NM_119604.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of plant-type hypersensitive response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of root morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fructose IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucose IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to mannitol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to sucrose IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    extra-large GTP-binding protein 2
    NP_195165.2
    • extra-large GTP-binding protein 2 (XLG2); FUNCTIONS IN: guanyl nucleotide binding, signal transducer activity; INVOLVED IN: in 7 processes; LOCATED IN: nucleus; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Guanine nucleotide binding protein (G-protein), alpha subunit (InterPro:IPR001019), G protein alpha subunit, helical insertion (InterPro:IPR011025); BEST Arabidopsis thaliana protein match is: extra-large G-protein 1 (TAIR:AT2G23460.1); Has 3202 Blast hits to 3201 proteins in 381 species: Archae - 0; Bacteria - 2; Metazoa - 2082; Fungi - 561; Plants - 350; Viruses - 0; Other Eukaryotes - 207 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16441086..16445017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119604.4 → NP_195165.2  extra-large GTP-binding protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195165.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6KIE6, Q9SZ04
      UniProtKB/TrEMBL
      A0A178V358, A0A5S9XZE8
      Conserved Domains (1) summary
      cd00066
      Location:464 → 840
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    2. NM_001342282.1 → NP_001328987.1  extra-large GTP-binding protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6B8, A0A654FVH4, A0A7G2F4Q1
      Conserved Domains (1) summary
      cd00066
      Location:464 → 801
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C6KIE6.1

    Gene LinkOut

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