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    SQS1 squalene synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829616, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SQS1
    Official Full Name
    squalene synthase 1
    Primary source
    TAIR:AT4G34640
    Locus tag
    AT4G34640
    See related
    Araport:AT4G34640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ERG9; SQUALENE SYNTHASE; squalene synthase 1; T4L20.220; T4L20_220
    Summary
    Encodes squalene synthase, which converts two molecules of farnesyl diphosphate (FPP) into squalene via an intermediate: presqualene diphosphate (PSPP). It is generally thought to be one of the key enzymes of sterol biosynthesis, since it catalyzes the first pathway-specific reaction of the sterol branch of the isoprenoid pathway.
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    Genomic context

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    See SQS1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (16538189..16542024)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene small subunit ribosomal protein 16 Neighboring gene prostatic spermine-binding-like protein Neighboring gene squalene synthase 2 Neighboring gene SH3 domain-containing protein Neighboring gene Ribosomal protein S3Ae

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and characterization of cDNAs encoding Arabidopsis thaliana squalene synthase. Nakashima T, et al. Proc Natl Acad Sci U S A, 1995 Mar 14. PMID 7892265, Free PMC Article
    2. Arabidopsis thaliana contains a single gene encoding squalene synthase. Busquets A, et al. Plant Mol Biol, 2008 May. PMID 18236008
    3. Cloning and characterization of the Arabidopsis thaliana SQS1 gene encoding squalene synthase--involvement of the C-terminal region of the enzyme in the channeling of squalene through the sterol pathway. Kribii R, et al. Eur J Biochem, 1997 Oct 1. PMID 9363754
    4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SQS1 is the only functional squalene synthase in Arabidopsis.
      Title: Arabidopsis thaliana contains a single gene encoding squalene synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342297.1
    NM_119630.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables farnesyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables squalene synthase [NAD(P)H] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables squalene synthase [NAD(P)H] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables squalene synthase [NAD(P)H] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    squalene synthase 1
    NP_195190.1
    • squalene synthase 1 (SQS1); FUNCTIONS IN: farnesyl-diphosphate farnesyltransferase activity; INVOLVED IN: sterol biosynthetic process; LOCATED IN: endoplasmic reticulum, plasma membrane, endoplasmic reticulum membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Squalene/phytoene synthase, conserved site (InterPro:IPR019845), Terpenoid synthase (InterPro:IPR008949), Farnesyl-diphosphate farnesyltransferase (InterPro:IPR006449), Squalene/phytoene synthase (InterPro:IPR002060); BEST Arabidopsis thaliana protein match is: squalene synthase 2 (TAIR:AT4G34650.1); Has 1469 Blast hits to 1468 proteins in 521 species: Archae - 28; Bacteria - 581; Metazoa - 114; Fungi - 174; Plants - 415; Viruses - 0; Other Eukaryotes - 157 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16538189..16542024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119630.4 → NP_195190.1  squalene synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195190.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53799
      UniProtKB/TrEMBL
      A0A178UT28, A0A5S9XYM7, A0A654FVH2
      Conserved Domains (1) summary
      TIGR01559
      Location:35 → 369
      squal_synth; farnesyl-diphosphate farnesyltransferase

    2. NM_001342297.1 → NP_001329728.1  squalene synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UT28, A0A1P8B8L3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53799.1

    Gene LinkOut

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