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    SYN1 Rad21/Rec8-like family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830432, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SYN1
    Official Full Name
    Rad21/Rec8-like family protein
    Primary source
    TAIR:AT5G05490
    Locus tag
    AT5G05490
    See related
    Araport:AT5G05490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtREC8; ATREC8; BP2; DETERMINATE; DIF1; INFERTILE 1; MOP10.3; MOP10_3; REC8; SYNAPTIC 1
    Summary
    Encodes a RAD21-like gene essential for meiosis. Encodes a 627 a.a. protein that is slightly longer in the N-terminus than SYN1 BP5.
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    Genomic context

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    See SYN1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    21
    Sequence:
    Chromosome: 5; NC_003076.8 (1624206..1629269)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene eukaryotic translation initiation factor 2 alpha subunit Neighboring gene Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A protein Neighboring gene Pollen Ole e 1 allergen and extensin family protein Neighboring gene Mad3/BUB1 homology region 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interacting Genomic Landscapes of REC8-Cohesin, Chromatin, and Meiotic Recombination in Arabidopsis. Lambing C, et al. Plant Cell, 2020 Apr. PMID 32024691, Free PMC Article
    2. Isolation and characterization of SYN1, a RAD21-like gene essential for meiosis in Arabidopsis. Bai X, et al. Plant Cell, 1999 Mar. PMID 10072401, Free PMC Article
    3. ASK1, a SKP1 homolog, is required for nuclear reorganization, presynaptic homolog juxtaposition and the proper distribution of cohesin during meiosis in Arabidopsis. Zhao D, et al. Plant Mol Biol, 2006 Sep. PMID 16897472
    4. SWI1 is required for meiotic chromosome remodeling events. Boateng KA, et al. Mol Plant, 2008 Jul. PMID 19825567
    5. AtREC8 and AtSCC3 are essential to the monopolar orientation of the kinetochores during meiosis. Chelysheva L, et al. J Cell Sci, 2005 Oct 15. PMID 16176934

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interacting Genomic Landscapes of REC8-Cohesin, Chromatin, and Meiotic Recombination in Arabidopsis.
      Title: Interacting Genomic Landscapes of REC8-Cohesin, Chromatin, and Meiotic Recombination in Arabidopsis.
    2. ASK1 is required for normal SYN1 distribution during meiotic prophase I and suggest that ask1 associated defects may be primarily related to SYN1 mislocalization.
      Title: ASK1, a SKP1 homolog, is required for nuclear reorganization, presynaptic homolog juxtaposition and the proper distribution of cohesin during meiosis in Arabidopsis.
    3. REC8 and SCC3 are necessary not only to maintain centromere cohesion at anaphase I, but also for the monopolar orientation of the kinetochores during the first meiotic division [AtREC8]
      Title: AtREC8 and AtSCC3 are essential to the monopolar orientation of the kinetochores during meiosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_120631.2
    NM_180442.2

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic sister chromatid cohesion, centromeric IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spindle attachment to meiosis I kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cohesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Rad21/Rec8-like family protein
    NP_196168.1
    • SYNAPTIC 1 (SYN1); CONTAINS InterPro DOMAIN/s: Rad21/Rec8 like protein, C-terminal (InterPro:IPR006909), Rad21/Rec8 like protein, N-terminal (InterPro:IPR006910); BEST Arabidopsis thaliana protein match is: sister chromatid cohesion 1 protein 4 (TAIR:AT5G16270.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_850773.1
    • SYNAPTIC 1 (SYN1); CONTAINS InterPro DOMAIN/s: Rad21/Rec8 like protein, C-terminal (InterPro:IPR006909), Rad21/Rec8 like protein, N-terminal (InterPro:IPR006910); BEST Arabidopsis thaliana protein match is: sister chromatid cohesion 1 protein 4 (TAIR:AT5G16270.1); Has 648 Blast hits to 629 proteins in 171 species: Archae - 0; Bacteria - 0; Metazoa - 226; Fungi - 209; Plants - 165; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1624206..1629269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180442.2 → NP_850773.1  Rad21/Rec8-like family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E9L1, Q9S7T7, Q9SQI1
      UniProtKB/TrEMBL
      A0A178UHG0
      Conserved Domains (2) summary
      pfam04824
      Location:573 → 627
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:16 → 117
      Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein

    2. NM_120631.2 → NP_196168.1  Rad21/Rec8-like family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196168.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UHG0, A0A5S9Y1W9, A0A654FZ23
      Conserved Domains (2) summary
      pfam04824
      Location:563 → 617
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:1 → 107
      Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7T7.2

    Gene LinkOut

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