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    RAD4 DNA repair protein Rad4 family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831525, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RAD4
    Official Full Name
    DNA repair protein Rad4 family
    Primary source
    TAIR:AT5G16630
    Locus tag
    AT5G16630
    See related
    Araport:AT5G16630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRAD4; MTG13.7; MTG13_7
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    Genomic context

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    See RAD4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (5454654..5459647)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene miscRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CENTRIN2 interacts with the Arabidopsis homolog of the human XPC protein (AtRAD4) and contributes to efficient synthesis-dependent repair of bulky DNA lesions. Liang L, et al. Plant Mol Biol, 2006 May. PMID 16786311
    2. RAD4 and RAD23/HMR Contribute to Arabidopsis UV Tolerance. Lahari T, et al. Genes (Basel), 2017 Dec 28. PMID 29283431, Free PMC Article
    3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAD4 interacts with the distal EF-hand Ca(2+) binding domain of CEN2 and this interaction is required for efficient nucleotide excision repair. [RAD4]
      Title: CENTRIN2 interacts with the Arabidopsis homolog of the human XPC protein (AtRAD4) and contributes to efficient synthesis-dependent repair of bulky DNA lesions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036817.3
    NM_121669.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UV protection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein Rad4 family
    NP_001031894.1
    • RAD4; FUNCTIONS IN: damaged DNA binding; INVOLVED IN: nucleotide-excision repair; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Transglutaminase-like (InterPro:IPR002931), DNA repair protein Rad4, DNA-binding domain 1 (InterPro:IPR018326), DNA repair protein Rad4, DNA-binding domain 3 (InterPro:IPR018328), DNA repair protein Rad4, DNA-binding domain 2 (InterPro:IPR018327), DNA repair protein Rad4, transglutaminase-like domain (InterPro:IPR018325), DNA repair protein Rad4 (InterPro:IPR004583); Has 662 Blast hits to 576 proteins in 184 species: Archae - 0; Bacteria - 0; Metazoa - 224; Fungi - 265; Plants - 79; Viruses - 0; Other Eukaryotes - 94 (source: NCBI BLink).
    NP_197166.2
    • RAD4; FUNCTIONS IN: damaged DNA binding; INVOLVED IN: nucleotide-excision repair; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Transglutaminase-like (InterPro:IPR002931), DNA repair protein Rad4, DNA-binding domain 1 (InterPro:IPR018326), DNA repair protein Rad4, DNA-binding domain 3 (InterPro:IPR018328), DNA repair protein Rad4, DNA-binding domain 2 (InterPro:IPR018327), DNA repair protein Rad4, transglutaminase-like domain (InterPro:IPR018325), DNA repair protein Rad4 (InterPro:IPR004583); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5454654..5459647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343458.1 → NP_001332636.1  DNA repair protein Rad4 family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1R7T387
      Conserved Domains (1) summary
      TIGR00605
      Location:107 → 618
      rad4; DNA repair protein rad4

    2. NM_001036817.3 → NP_001031894.1  DNA repair protein Rad4 family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031894.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W489
      UniProtKB/TrEMBL
      A0A178UQJ6, A0A5S9Y4Q4
      Conserved Domains (1) summary
      TIGR00605
      Location:107 → 781
      rad4; DNA repair protein rad4

    3. NM_121669.3 → NP_197166.2  DNA repair protein Rad4 family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197166.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W489
      UniProtKB/TrEMBL
      A0A178UQJ6, A0A5S9Y4Q4
      Conserved Domains (1) summary
      TIGR00605
      Location:107 → 781
      rad4; DNA repair protein rad4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W489.1

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