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    SAG12 senescence-associated gene 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834629, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAG12
    Official Full Name
    senescence-associated gene 12
    Primary source
    TAIR:AT5G45890
    Locus tag
    AT5G45890
    See related
    Araport:AT5G45890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtSAG12; CI0010; K15I22.9; K15I22_9; senescence-associated gene 12
    Summary
    Senescence-associated gene 12 (SAG12) encoding a cysteine protease influenced by cytokinin, auxin, and sugars.Localized to special vacuole found during senescence called senescence associated vacuoles which are different from central vacuole in the tonoplast composition and pH.
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    Genomic context

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    See SAG12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (18613239..18614963)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene SCR-like 27 Neighboring gene Pollen Ole e 1 allergen and extensin family protein Neighboring gene ThiF family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ethylene is involved in pistil fate by modulating the onset of ovule senescence and the GA-mediated fruit set in Arabidopsis. Carbonell-Bejerano P, et al. BMC Plant Biol, 2011 May 16. PMID 21575215, Free PMC Article
    2. Regulation of flooding tolerance of SAG12:ipt Arabidopsis plants by cytokinin. Huynh le N, et al. J Exp Bot, 2005 May. PMID 15797940
    3. Ultraviolet-B exposure leads to up-regulation of senescence-associated genes in Arabidopsis thaliana. John CF, et al. J Exp Bot, 2001 Jun. PMID 11432956
    4. Identification of a promoter region responsible for the senescence-specific expression of SAG12. Noh YS, et al. Plant Mol Biol, 1999 Sep. PMID 10579486
    5. Effects of cytokinin production under two SAG promoters on senescence and development of tomato plants. Swartzberg D, et al. Plant Biol (Stuttg), 2006 Sep. PMID 16883480

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The senescence is initiated in shm1-1 under photorespiratory conditions. Transcription of the senescence marker SAG12 is enhanced in shm1-1.
      Title: D-2-hydroxyglutarate metabolism is linked to photorespiration in the shm1-1 mutant.
    2. RT-PCR studies were performed to quantify SAG12 gene expression in waterlogged plants.
      Title: Regulation of flooding tolerance of SAG12:ipt Arabidopsis plants by cytokinin.
    3. Two promoters of senescence-associated ARABIDOPSIS genes, SAG12 and SAG13, were used in tomato plants to express IPT that catalyzes the rate-limiting step in cytokinin biosynthesis.
      Title: Effects of cytokinin production under two SAG promoters on senescence and development of tomato plants.
    4. The localization and function of vacuolar compartments containing SAG12 in senescing leaves of A. thaliana and G. max transgenics.
      Title: Senescence-associated vacuoles with intense proteolytic activity develop in leaves of Arabidopsis and soybean.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_123957.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in floral organ senescence IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in leaf senescence IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to UV-B IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cytokinin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IEP
    Inferred from Expression Pattern
    more info
    		  
    involved_in response to fructose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in senescence-associated vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    senescence-associated gene 12
    NP_568651.1
    • senescence-associated gene 12 (SAG12); CONTAINS InterPro DOMAIN/s: Peptidase C1A, papain (InterPro:IPR013128), Proteinase inhibitor I29, cathepsin propeptide (InterPro:IPR013201), Peptidase C1A, papain C-terminal (InterPro:IPR000668), Peptidase, cysteine peptidase active site (InterPro:IPR000169); BEST Arabidopsis thaliana protein match is: Cysteine proteinases superfamily protein (TAIR:AT3G49340.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18613239..18614963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123957.3 → NP_568651.1  senescence-associated gene 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568651.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38886, Q8H7B7, Q9FJ47
      UniProtKB/TrEMBL
      A0A178UR44, A0A5S9YBX8, A0A654G895
      Conserved Domains (2) summary
      smart00848
      Location:38 → 95
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:130 → 345
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJ47.1

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