VDAC3 voltage dependent anion channel 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: VDAC3
Official Full Name: voltage dependent anion channel 3
Primary source: TAIR:AT5G15090
Locus tag: AT5G15090
See related: Araport:AT5G15090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 3; ATVDAC3; F2G14.210; F2G14_210; voltage dependent anion channel 3
Summary: Encodes a voltage-dependent anion channel (VDAC: AT3G01280/VDAC1, AT5G67500/VDAC2, AT5G15090/VDAC3, AT5G57490/VDAC4, AT5G15090/VDAC5). VDACs are reported to be porin-type, beta-barrel diffusion pores. They are prominently localized in the outer mitochondrial membrane and are involved in metabolite exchange between the organelle and the cytosol.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See VDAC3 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (4888964..4891603, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Voltage-dependent anion channel 3 (VDAC3) mediates P. syringae induced ABA-SA signaling crosstalk in Arabidopsis thaliana.
Title: Voltage-dependent anion channel 3 (VDAC3) mediates P. syringae induced ABA-SA signaling crosstalk in Arabidopsis thaliana.
Mitochondrial VOLTAGE-DEPENDENT ANION CHANNEL 3 regulates stomatal closure by abscisic acid signaling.
Title: Mitochondrial VOLTAGE-DEPENDENT ANION CHANNEL 3 regulates stomatal closure by abscisic acid signaling.
CIPK9 targets VDAC3 and modulates oxidative stress responses in Arabidopsis.
Title: CIPK9 targets VDAC3 and modulates oxidative stress responses in Arabidopsis.
HSP70-16 and VDAC3 jointly inhibit seed germination under cold stress in Arabidopsis.
Title: HSP70-16 and VDAC3 jointly inhibit seed germination under cold stress in Arabidopsis.
Results indicate that both AtVDAC3 and AtTrx m2 are involved in ROS signaling and play opposite roles in NaCl stress response.
Title: Arabidopsis mitochondrial voltage-dependent anion channel 3 (AtVDAC3) protein interacts with thioredoxin m2.
VDAC3 has a large conductance and is open at or around 0 mV and closes at positive or negative voltages.VDAC3 exhibits both fast and slow kinetics.
Title: Channel characteristics of VDAC-3 from Arabidopsis thaliana.
Alternative cleavage and polyadenylation produces two major isoforms of VDAC3; the longest mRNA is targeted to the mitochondrial surface
Title: Differential targeting of VDAC3 mRNA isoforms influences mitochondria morphology.
AtVDAC3 is in abundance in plasma membrane.
Title: Voltage-dependent-anion-channels (VDACs) in Arabidopsis have a dual localization in the cell but show a distinct role in mitochondria.
VDAC3 expression is low compared with other VDAC members and its knockout mutant does not show any clear phenotype.
Title: Molecular and genetic characterization of the gene family encoding the voltage-dependent anion channel in Arabidopsis.
The plant-specific kinesin, KP1, specifically interacts with VDAC3 on the mitochondrial outer membrane and that both KP1 and VDAC3 regulate aerobic respiration during seed germination at low temperature.
Title: Arabidopsis kinesin KP1 specifically interacts with VDAC3, a mitochondrial protein, and regulates respiration during seed germination at low temperature.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_001203385.1

Supported by ESTs:

NM_121513.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic anion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of seed germination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
NOT located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast envelope	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in nucleolus	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
located_in vacuole	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: voltage dependent anion channel 3

NP_001190314.1

voltage dependent anion channel 3 (VDAC3); CONTAINS InterPro DOMAIN/s: Porin, eukaryotic type (InterPro:IPR001925); BEST Arabidopsis thaliana protein match is: voltage dependent anion channel 1 (TAIR:AT3G01280.1).

NP_197013.1

voltage dependent anion channel 3 (VDAC3); FUNCTIONS IN: voltage-gated anion channel activity; INVOLVED IN: defense response to bacterium, response to bacterium, anion transport; LOCATED IN: in 10 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Porin, eukaryotic type (InterPro:IPR001925); BEST Arabidopsis thaliana protein match is: voltage dependent anion channel 1 (TAIR:AT3G01280.1); Has 896 Blast hits to 896 proteins in 198 species: Archae - 0; Bacteria - 2; Metazoa - 411; Fungi - 154; Plants - 298; Viruses - 0; Other Eukaryotes - 31 (source: NCBI BLink).