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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001199431.2 → NP_001186360.2 DNA (cytosine-5)-methyltransferase 1 isoform 1
See identical proteins and their annotated locations for NP_001186360.2
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) encodes the longest protein (isoform 1). This variant has two upstream in-frame AUGs but N-terminal sequencing and western analysis from PMID: 9830015 (Table I and Figure 2) support the use of the third in-frame AUG.
- Source sequence(s)
-
AC170598
- Consensus CDS
-
CCDS57655.1
- UniProtKB/Swiss-Prot
- P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6
- UniProtKB/TrEMBL
-
Q3UHZ3
- Related
- ENSMUSP00000004202.10, ENSMUST00000004202.17
- Conserved Domains (7) summary
-
- COG0270
Location:1141 → 1594
- Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
- cd04711
Location:969 → 1104
- BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- cd04760
Location:758 → 881
- BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- pfam02008
Location:648 → 694
- zf-CXXC; CXXC zinc finger domain
- pfam05029
Location:124 → 331
- TIMELESS_C; Timeless protein C terminal region
- pfam06464
Location:16 → 106
- DMAP_binding; DMAP1-binding Domain
- pfam12047
Location:405 → 540
- DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
-
NM_001199432.2 → NP_001186361.1 DNA (cytosine-5)-methyltransferase 1 isoform 3
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) uses an alternate first exon, which results in the use of a downstream start codon, and an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus compared to isoform 1.
- Source sequence(s)
-
AC170598
- Consensus CDS
-
CCDS57653.1
- UniProtKB/TrEMBL
- J3QNW0, Q3UHZ3
- Related
- ENSMUSP00000136982.2, ENSMUST00000177754.9
- Conserved Domains (6) summary
-
- COG0270
Location:1022 → 1475
- Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
- cd04711
Location:850 → 985
- BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- cd04760
Location:639 → 762
- BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- pfam02008
Location:529 → 575
- zf-CXXC; CXXC zinc finger domain
- pfam05029
Location:106 → 212
- TIMELESS_C; Timeless protein C terminal region
- pfam12047
Location:286 → 421
- DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
-
NM_001199433.2 → NP_001186362.1 DNA (cytosine-5)-methyltransferase 1 isoform 4
See identical proteins and their annotated locations for NP_001186362.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) uses an alternate first exon, which results in use of a downstream start codon compared to variant 1. The resulting protein (isoform 4) has a shorter N-terminus than isoform 1.
- Source sequence(s)
-
AC170598
- Consensus CDS
-
CCDS57654.1
- UniProtKB/TrEMBL
-
Q3UHZ3
- Related
- ENSMUSP00000150433.2, ENSMUST00000216540.2
- Conserved Domains (6) summary
-
- COG0270
Location:1023 → 1476
- Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
- cd04711
Location:851 → 986
- BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- cd04760
Location:640 → 763
- BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- pfam02008
Location:530 → 576
- zf-CXXC; CXXC zinc finger domain
- pfam05029
Location:6 → 213
- TIMELESS_C; Timeless protein C terminal region
- pfam12047
Location:287 → 422
- DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
-
NM_001314011.2 → NP_001300940.1 DNA (cytosine-5)-methyltransferase 1 isoform 5
Status: VALIDATED
- Description
- Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 5, which is longer than isoform 1. This variant has two upstream in-frame AUGs but N-terminal sequencing and western analysis from PMID: 9830015 (Table I and Figure 2) support the use of the third in-frame AUG.
- Source sequence(s)
-
AC170598
- UniProtKB/TrEMBL
- Q3UHZ3, Q7TSJ0
- Conserved Domains (6) summary
-
- COG0270
Location:1148 → 1601
- Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
- cd04711
Location:976 → 1111
- BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- cd04760
Location:765 → 888
- BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- pfam02008
Location:655 → 701
- zf-CXXC; CXXC zinc finger domain
- pfam06464
Location:16 → 106
- DMAP_binding; DMAP1-binding Domain
- pfam12047
Location:412 → 547
- DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
-
NM_001404685.2 → NP_001391614.2 DNA (cytosine-5)-methyltransferase 1 isoform 6
Status: VALIDATED
- Source sequence(s)
-
AC170598
- UniProtKB/TrEMBL
-
Q3UHZ3
-
NM_010066.5 → NP_034196.5 DNA (cytosine-5)-methyltransferase 1 isoform 2
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is one amino acid shorter than isoform 1. This variant has two upstream in-frame AUGs but N-terminal sequencing and western analysis from PMID: 9830015 (Table I and Figure 2) support the use of the third in-frame AUG.
- Source sequence(s)
-
AC170598
- UniProtKB/TrEMBL
-
Q3UHZ3
- Conserved Domains (6) summary
-
- COG0270
Location:1140 → 1593
- Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
- cd04711
Location:968 → 1103
- BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- cd04760
Location:757 → 880
- BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- pfam02008
Location:647 → 693
- zf-CXXC; CXXC zinc finger domain
- pfam06464
Location:16 → 106
- DMAP_binding; DMAP1-binding Domain
- pfam12047
Location:404 → 539
- DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCm39 C57BL/6J
Genomic
-
NC_000075.7 Reference GRCm39 C57BL/6J
- Range
-
20818501..20871084 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011242393.3 → XP_011240695.1 DNA (cytosine-5)-methyltransferase 1 isoform X2
- UniProtKB/TrEMBL
-
Q3UHZ3
- Conserved Domains (6) summary
-
- PHA03169
Location:68 → 198
- PHA03169; hypothetical protein; Provisional
- COG0270
Location:1030 → 1483
- Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
- cd04711
Location:858 → 993
- BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- cd04760
Location:647 → 770
- BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
- pfam02008
Location:537 → 583
- zf-CXXC; CXXC zinc finger domain
- pfam12047
Location:298 → 427
- DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain