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    Ndufv3 NADH:ubiquinone oxidoreductase core subunit V3 [ Mus musculus (house mouse) ]

    Gene ID: 78330, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ndufv3provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit V3provided by MGI
    Primary source
    MGI:MGI:1890894
    See related
    Ensembl:ENSMUSG00000024038 AllianceGenome:MGI:1890894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500032D16Rik
    Summary
    Predicted to be involved in mitochondrial ATP synthesis coupled electron transport. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human NDUFV3 (NADH:ubiquinone oxidoreductase subunit V3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 60.1), kidney adult (RPKM 42.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufv3 in Genome Data Viewer
    Location:
    17 B1; 17 16.64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31739089..31750300)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31520115..31531326)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 9A Neighboring gene predicted gene 9902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31649222-31649405 Neighboring gene WD repeat domain 4 Neighboring gene STARR-positive B cell enhancer ABC_E3197 Neighboring gene STARR-positive B cell enhancer ABC_E9439 Neighboring gene predicted gene, 50105 Neighboring gene Pbx/knotted 1 homeobox Neighboring gene STARR-seq mESC enhancer starr_42341

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and evolutionary analysis of tissue-specific isoforms of mitochondrial complex I subunit NDUFV3. Guerrero-Castillo S, et al. Biochim Biophys Acta Bioenerg, 2017 Mar. PMID 27988283
    2. Evolutionary breakpoints on human chromosome 21. Davisson MT, et al. Genomics, 2001 Nov. PMID 11707078
    3. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
    4. SCAF1 drives the compositional diversity of mammalian respirasomes. Vercellino I, et al. Nat Struct Mol Biol, 2024 Jul. PMID 38575788
    5. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial ATP synthesis coupled electron transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial ATP synthesis coupled electron transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
    Names
    CI-9kD
    NADH dehydrogenase (ubiquinone) flavoprotein 3
    NADH-ubiquinone oxidoreductase 9 kDa subunit
    NADH-ubiquinone oxidoreductase flavoprotein 3
    complex I-9kD
    NP_001077360.1
    NP_084363.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083891.1 → NP_001077360.1  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001077360.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK077433, BU555486, BU755401
      Consensus CDS
      CCDS37550.1
      UniProtKB/Swiss-Prot
      Q8BK30
      Related
      ENSMUSP00000066303.9, ENSMUST00000064798.16
      Conserved Domains (1) summary
      pfam15880
      Location:63 → 97
      NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

    2. NM_030087.2 → NP_084363.2  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_084363.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC166172, BF318157, BU555486, BU755401, BY064612
      Consensus CDS
      CCDS37549.1
      UniProtKB/TrEMBL
      Q3U422, Q91WP8
      Related
      ENSMUSP00000049000.9, ENSMUST00000046288.16
      Conserved Domains (1) summary
      pfam15880
      Location:427 → 460
      NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31739089..31750300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BK30.1 GenPept UniProtKB/Swiss-Prot:Q8BK30

    Gene LinkOut

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