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    Slc25A46b Solute carrier family 25 member 46b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25A46bprovided by FlyBase
    Official Full Name
    Solute carrier family 25 member 46bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032664
    Locus tag
    Dmel_CG5755
    See related
    AllianceGenome:FB:FBgn0032664
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.163; CG5755; Dmel\CG5755; dSLC25A46; dSlc25A46b; dSLC25A46b; Slc25A46; SLC25A46b
    Summary
    Predicted to be involved in mitochondrial fission. Located in mitochondrial membrane and plasma membrane. Is expressed in adult head. Used to study neuropathy. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1E. Orthologous to human SLC25A46 (solute carrier family 25 member 46). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Slc25A46b in Genome Data Viewer
    Location:
    36E4-36E4; 2-53 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18096568..18098120)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18096568..18098120)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel Drosophila model for mitochondrial diseases by targeting of a solute carrier protein SLC25A46. Suda K, et al. Brain Res, 2018 Jun 15. PMID 29604258
    2. Neuron-specific knockdown of solute carrier protein SLC25A46a induces locomotive defects, an abnormal neuron terminal morphology, learning disability, and shortened lifespan. Ali MS, et al. IBRO Rep, 2020 Jun. PMID 32140609, Free PMC Article
    3. Reduction of Rpd3 suppresses defects in locomotive ability and neuronal morphology induced by the knockdown of Drosophila SLC25A46 via an epigenetic pathway. Suda K, et al. Exp Cell Res, 2019 Dec 15. PMID 31614134
    4. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
    5. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial membrane fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 25 member 46b
    Names
    CG5755-PA
    Slc25A46b-PA
    solute carrier family 25 member 46

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18096568..18098120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136020.3 → NP_609864.1  solute carrier family 25 member 46b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T905, Q9VJA5
      Related
      FBpp0080586
      Conserved Domains (1) summary
      pfam00153
      Location:305 → 388
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T905 Q8T905
    Q9VJA5 Q9VJA5

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