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    CG12147 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40651, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12147provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037325
    Locus tag
    Dmel_CG12147
    See related
    AllianceGenome:FB:FBgn0037325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CKIalpha like; CKIalpha-like II; Dmel\CG12147
    Summary
    Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including endocytosis; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12147 in Genome Data Viewer
    Location:
    83A2-83A2; 3-47.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5425369..5427257, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1251091..1252979, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor co-receptor Neighboring gene uncharacterized protein Neighboring gene pancreatic eIF-2alpha kinase Neighboring gene Ribosomal protein L35A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of casein kinase 1 and functional analysis of new doubletime mutants in Drosophila. Thakkar N, et al. Front Physiol, 2022. PMID 36589447, Free PMC Article
    2. Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Meng Z, et al. Mol Biol Cell, 2011 Aug 15. PMID 21680713, Free PMC Article
    3. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Jia J, et al. Dev Cell, 2005 Dec. PMID 16326393
    4. Regulation of wingless signaling by the CKI family in Drosophila limb development. Zhang L, et al. Dev Biol, 2006 Nov 1. PMID 16987508, Free PMC Article
    5. Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling. Serysheva E, et al. EMBO Rep, 2013 Aug. PMID 23797875, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12147-PA
    CKIa-like
    NP_649536.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5425369..5427257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141279.2 → NP_649536.1  uncharacterized protein Dmel_CG12147 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWT4
      Related
      FBpp0078437, FBtr0078793
      Conserved Domains (2) summary
      COG0515
      Location:67 → 306
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14016
      Location:67 → 331
      STKc_CK1; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JWT4 Q7JWT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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