U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    eIF4B eukaryotic translation initiation factor 4B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355041, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    eIF4Bprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 4Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020660
    Locus tag
    Dmel_CG10837
    See related
    AllianceGenome:FB:FBgn0020660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10837; Dm-eIF4B; Dmel\CG10837; eIF-4b; eIF-4B; EIF-4B; eIF-4B-L; eIF-4B-S; eIf4b; Eif4B; EIF4B; eIF4B-L; eIF4B-S
    Summary
    Enables translation initiation factor activity. Involved in translational initiation. Located in cytosol. Is expressed in adult brain cell body rind; adult head; and organism. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See eIF4B in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (27842669..27858271, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (2901758..2917360)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein L15 Neighboring gene long non-coding RNA:CR46250 Neighboring gene Dead box protein 80 Neighboring gene long non-coding RNA:CR46482 Neighboring gene pseudo Neighboring gene lethal (3) 80Fj

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Heat shock effects on phosphorylation of protein synthesis initiation factor proteins eIF-4E and eIF-2 alpha in Drosophila. Duncan RF, et al. Biochemistry, 1995 Mar 7. PMID 7893711
    2. Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence. McGurk L, et al. Hum Mol Genet, 2021 Sep 15. PMID 34077532, Free PMC Article
    3. Two functionally redundant isoforms of Drosophila melanogaster eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation. Hernández G, et al. Eur J Biochem, 2004 Jul. PMID 15233788
    4. The insulin receptor cellular IRES confers resistance to eIF4A inhibition. Olson CM, et al. Elife, 2013 Jul 16. PMID 23878722, Free PMC Article
    5. Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles. Lacroix E, et al. Front Mol Biosci, 2022. PMID 36203874, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that two functionally redundant isoforms of Drosophila eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation.
      Title: Two functionally redundant isoforms of Drosophila melanogaster eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translational initiation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    eukaryotic translation initiation factor 4B
    Names
    CG10837-PA
    CG10837-PB
    CG10837-PE
    CG10837-PF
    eIF4B-PA
    eIF4B-PB
    eIF4B-PE
    eIF4B-PF
    eukaryotic initiation factor 4B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      27842669..27858271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276232.1 → NP_001263161.1  eukaryotic translation initiation factor 4B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7EEF1
      Conserved Domains (2) summary
      COG0724
      Location:72 → 268
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12402
      Location:79 → 155
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

    2. NM_001015319.2 → NP_001015319.1  eukaryotic translation initiation factor 4B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PLL3
      Conserved Domains (2) summary
      COG0724
      Location:72 → 268
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12402
      Location:79 → 155
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

    3. NM_001015320.2 → NP_001015320.1  eukaryotic translation initiation factor 4B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PLL1
      Conserved Domains (2) summary
      COG0724
      Location:72 → 268
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12402
      Location:79 → 155
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

    4. NM_001015321.2 → NP_001015321.1  eukaryotic translation initiation factor 4B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYL3
      Conserved Domains (2) summary
      COG0724
      Location:72 → 268
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12402
      Location:79 → 155
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    L7EEF1 L7EEF1
    Q7PLL1 Q7PLL1
    Q7PLL3 Q7PLL3
    Q8SYL3 Q8SYL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.