U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    arx asterix [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40061, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    arxprovided by FlyBase
    Official Full Name
    asterixprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036826
    Locus tag
    Dmel_CG3893
    See related
    AllianceGenome:FB:FBgn0036826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Arx; BcDNA:LD18018; CG3893; Dmel\CG3893; DmGTSF1; gtsf1; Gtsf1
    Summary
    Enables tRNA binding activity. Involved in negative regulation of DNA-templated transcription; oogenesis; and regulatory ncRNA-mediated gene silencing. Located in nucleus. Is expressed in egg chamber; female germline cell; organism; ovary; and somatic cell of ovariole. Orthologous to human GTSF1 (gametocyte specific factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See arx in Genome Data Viewer
    Location:
    75E4-75E4; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18900595..18901554, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18893695..18894654, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Ribosomal protein L26 Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 1b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons. Ipsaro JJ, et al. Cell Rep, 2021 Mar 30. PMID 33789107, Free PMC Article
    2. Crystal structure of Drosophila Piwi. Yamaguchi S, et al. Nat Commun, 2020 Feb 12. PMID 32051406, Free PMC Article
    3. Mechanism and regulation of P element transposition. Ghanim GE, et al. Open Biol, 2020 Dec. PMID 33352068, Free PMC Article
    4. Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing. Murano K, et al. EMBO J, 2019 Sep 2. PMID 31368590, Free PMC Article
    5. Non-Coding RNAs in Transcriptional Regulation: The review for Current Molecular Biology Reports. Chen YA, et al. Curr Mol Biol Rep, 2015 Mar 1. PMID 26120554, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
      Title: Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
    2. CG3893 is indispensible for transposon silencing but does not affect piRNA levels.
      Title: A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transposable element silencing by piRNA-mediated heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    asterix
    Names
    CG3893-PA
    arx-PA
    gametocyte-specific factor 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18900595..18901554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140814.2 → NP_649071.1  asterix [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649071.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SWX0, Q9VVU3
      Related
      FBpp0074842
      Conserved Domains (1) summary
      pfam05253
      Location:4 → 25
      zf-U11-48K; U11-48K-like CHHC zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SWX0.1 Q8SWX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools