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    Jon25Bii Jonah 25Bii [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon25Biiprovided by FlyBase
    Official Full Name
    Jonah 25Biiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031654
    Locus tag
    Dmel_CG8869
    See related
    AllianceGenome:FB:FBgn0031654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    25B; CG8869; Dmel\CG8869; Jon25; Jon25B; Jon25ii; SP112
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jon25Bii in Genome Data Viewer
    Location:
    25B4-25B4; 2-14 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4952243..4953136, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4952243..4953136, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene beta subunit of type I geranylgeranyl transferase Neighboring gene jetlag Neighboring gene Jonah 25Biii Neighboring gene Jonah 25Bi Neighboring gene Marcal1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The intestinal stem cell/enteroblast-GAL4 driver, escargot-GAL4, also manipulates gene expression in the juvenile hormone-synthesizing organ of Drosophila melanogaster. Kurogi Y, et al. Sci Rep, 2024 Apr 26. PMID 38671036, Free PMC Article
    2. The detection of Jonah gene transcripts in Drosophila by in situ hybridization. Akam ME, et al. EMBO J, 1985 Jan. PMID 2410252, Free PMC Article
    3. Developmental and functional analysis of Jonah gene expression. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416611
    4. Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults. Yang H, et al. BMC Genomics, 2017 May 18. PMID 28521739, Free PMC Article
    5. Juvenile hormone regulation of Drosophila aging. Yamamoto R, et al. BMC Biol, 2013 Jul 17. PMID 23866071, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 25Bii
    Names
    CG8869-PA
    CG8869-PB
    Jon25Bii-PA
    Jon25Bii-PB
    jonah 25B
    NP_001285608.1
    NP_608882.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4952243..4953136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298679.1 → NP_001285608.1  jonah 25Bii, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P28, Q9VMX8
      Conserved Domains (2) summary
      smart00020
      Location:42 → 268
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:43 → 271
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_135038.2 → NP_608882.1  jonah 25Bii, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608882.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P28, Q9VMX8
      Related
      FBpp0078691
      Conserved Domains (2) summary
      smart00020
      Location:42 → 268
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:43 → 271
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P28 Q86P28
    Q9VMX8 Q9VMX8

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