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    Past1 Putative Achaete Scute Target 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41569, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Past1provided by FlyBase
    Official Full Name
    Putative Achaete Scute Target 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0016693
    Locus tag
    Dmel_CG6148
    See related
    AllianceGenome:FB:FBgn0016693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6148; CG66148; dEHD; dEHD1; Dmel\CG6148; Ehd; PAST; Past-1; PAST-1; past1; PAST1
    Summary
    Predicted to enable GTP binding activity and calcium ion binding activity. Involved in several processes, including compound eye photoreceptor cell differentiation; germ cell development; and imaginal disc-derived wing morphogenesis. Located in subsynaptic reticulum. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; gut section; and larval muscle cell. Orthologous to several human genes including EHD1 (EH domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Past1 in Genome Data Viewer
    Location:
    87C6-87C6; 3-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12697322..12704875)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8523044..8530597)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 1 Neighboring gene uncharacterized protein Neighboring gene Ninjurin C Neighboring gene uncharacterized protein Neighboring gene DNA polymerase theta Neighboring gene Malic enzyme

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Wolbachia WalE1 effector alters Drosophila endocytosis. Martin M, et al. PLoS Pathog, 2024 Mar. PMID 38547310, Free PMC Article
    2. Past1 Modulates Drosophila Eye Development. Dorot O, et al. PLoS One, 2017. PMID 28060904, Free PMC Article
    3. The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Smith CA, et al. Mol Biol Cell, 2004 Aug. PMID 15155807, Free PMC Article
    4. The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic function. Koles K, et al. Mol Biol Cell, 2015 Sep 15. PMID 26202464, Free PMC Article
    5. Drosophila Past1 is involved in endocytosis and is required for germline development and survival of the adult fly. Olswang-Kutz Y, et al. J Cell Sci, 2009 Feb 15. PMID 19174465

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic interaction was found between Past1 and members of the Notch signaling pathway, suggesting a role for Past1 in this developmentally crucial signaling pathway.
      Title: Drosophila Past1 is involved in endocytosis and is required for germline development and survival of the adult fly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in R1/R6 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in R7 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subsynaptic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in subsynaptic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative achaete scute target 1
    Names
    CG6148-PA
    CG6148-PB
    EH domain containing protein
    Past1-PA
    Past1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12697322..12704875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169478.2 → NP_731737.1  putative achaete scute target 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731737.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGN0, Q8T8W3
      Related
      FBpp0082123
      Conserved Domains (4) summary
      smart00027
      Location:446 → 538
      EH; Eps15 homology domain
      cd09913
      Location:63 → 303
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:27 → 59
      EHD_N; N-terminal EH-domain containing protein
      pfam18150
      Location:291 → 397
      DUF5600; Domain of unknown function (DUF5600)

    2. NM_079608.3 → NP_524332.2  putative achaete scute target 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524332.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGN0, Q8T6I0, Q9VG34
      Related
      FBpp0082124
      Conserved Domains (4) summary
      smart00027
      Location:440 → 532
      EH; Eps15 homology domain
      cd09913
      Location:57 → 297
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:21 → 53
      EHD_N; N-terminal EH-domain containing protein
      pfam18150
      Location:285 → 391
      DUF5600; Domain of unknown function (DUF5600)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGN0 Q8IGN0
    Q8T6I0 Q8T6I0
    Q8T8W3 Q8T8W3
    Q94919 Q94919

    Gene LinkOut

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