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    CG5377 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42645, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG5377provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038974
    Locus tag
    Dmel_CG5377
    See related
    AllianceGenome:FB:FBgn0038974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5377
    Summary
    Enables serine hydrolase activity. Predicted to be located in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5377 in Genome Data Viewer
    Location:
    94A16-94A16; 3-74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22466905..22468157, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18292627..18293879, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylethanolamine-binding protein 1 Neighboring gene Neurexin 1 Neighboring gene mir-4952 stem loop Neighboring gene Prefoldin 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article
    2. Time-resolved mapping of genetic interactions to model rewiring of signaling pathways. Heigwer F, et al. Elife, 2018 Dec 28. PMID 30592458, Free PMC Article
    3. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    4. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-amino-acid esterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5377-PA
    NP_651052.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22466905..22468157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142795.4 → NP_651052.1  uncharacterized protein Dmel_CG5377 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRU8, Q9VD00
      Related
      FBpp0083686
      Conserved Domains (2) summary
      COG0596
      Location:26 → 274
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:45 → 257
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRU8 Q8MRU8
    Q9VD00 Q9VD00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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