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    CG11247 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40414, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG11247provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037120
    Locus tag
    Dmel_CG11247
    See related
    AllianceGenome:FB:FBgn0037120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11247
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; larval muscle cell; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11247 in Genome Data Viewer
    Location:
    78E5-78E5; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21724326..21728806, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21717426..21721906, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43978 Neighboring gene Seminal fluid protein 78E Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II, I and III subunit H Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals. Doupé DP, et al. Proc Natl Acad Sci U S A, 2018 Nov 27. PMID 30404917, Free PMC Article
    2. Mes2, a MADF-containing transcription factor essential for Drosophila development. Zimmermann G, et al. Dev Dyn, 2006 Dec. PMID 17029287
    3. An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation. Chen J, et al. RNA, 2012 Dec. PMID 23097424, Free PMC Article
    4. A protein network-guided screen for cell cycle regulators in Drosophila. Guest ST, et al. BMC Syst Biol, 2011 May 6. PMID 21548953, Free PMC Article
    5. Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Stark A, et al. Cell, 2005 Dec 16. PMID 16337999

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11247-PA
    CG11247-PB
    CG11247-PC
    CG11247-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21724326..21728806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141094.5 → NP_649351.2  uncharacterized protein Dmel_CG11247, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649351.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9G3, Q9VNZ4
      Related
      FBpp0078113
      Conserved Domains (5) summary
      COG5048
      Location:88 → 247
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:295 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:165 → 189
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001104189.2 → NP_001097659.1  uncharacterized protein Dmel_CG11247, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097659.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9G3, Q9VNZ4
      Conserved Domains (5) summary
      COG5048
      Location:88 → 247
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:295 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:165 → 189
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001275260.1 → NP_001262189.1  uncharacterized protein Dmel_CG11247, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD91
      Conserved Domains (4) summary
      COG5048
      Location:5 → 173
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:99 → 119
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:14 → 40
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:113 → 136
      zf-H2C2_2; Zinc-finger double domain

    4. NM_168936.3 → NP_730680.1  uncharacterized protein Dmel_CG11247, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9G3, Q9VNZ4
      Related
      FBpp0078112
      Conserved Domains (5) summary
      COG5048
      Location:88 → 247
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:295 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:165 → 189
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD91 M9PD91
    Q8T9G3 Q8T9G3
    Q9VNZ4 Q9VNZ4

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