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    Spf45 Spf45 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355114, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spf45provided by FlyBase
    Official Full Name
    Spf45provided by FlyBase
    Primary source
    FLYBASE:FBgn0086683
    Locus tag
    Dmel_CG17540
    See related
    AllianceGenome:FB:FBgn0086683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17540; Dmel\CG17540; dRBM17; dSPF45; RBM17; spf-45; spf45; SPF45
    Summary
    Predicted to enable RNA binding activity. Involved in DNA repair; compound eye morphogenesis; and regulation of alternative mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in organism. Orthologous to human RBM17 (RNA binding motif protein 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spf45 in Genome Data Viewer
    Location:
    40F7-40F7; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (23066874..23068386, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22959606..22961118, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene concertina Neighboring gene Chitinase 10 Neighboring gene long non-coding RNA:CR43242 Neighboring gene uncharacterized protein Neighboring gene mir-2490 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45. Lallena MJ, et al. Cell, 2002 May 3. PMID 12015979
    2. U2AF homology motifs: protein recognition in the RRM world. Kielkopf CL, et al. Genes Dev, 2004 Jul 1. PMID 15231733, Free PMC Article
    3. Sex, AGility, and the regulation of alternative splicing. Graveley BR. Cell, 2002 May 17. PMID 12086596
    4. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Lim J, et al. Nature, 2008 Apr 10. PMID 18337722, Free PMC Article
    5. Drosophila SPF45: a bifunctional protein with roles in both splicing and DNA repair. Chaouki AS, et al. PLoS Genet, 2006 Dec 8. PMID 17154718, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    Spf45
    Names
    CG17540-PA
    CG17540-PB
    CG17540-PC
    RNA binding motif protein 1
    Spf45-PA
    Spf45-PB
    Spf45-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      23066874..23068386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042960.3 → NP_001036425.1  Spf45, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PL81, Q8SYI1
      Conserved Domains (2) summary
      cd12647
      Location:275 → 370
      RRM_UHM_SPF45; RNA recognition motif in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
      pfam01585
      Location:177 → 216
      G-patch; G-patch domain

    2. NM_001042961.3 → NP_001036426.1  Spf45, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PL83, Q8SYI1
      Conserved Domains (2) summary
      cd12647
      Location:307 → 402
      RRM_UHM_SPF45; RNA recognition motif in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
      pfam01585
      Location:209 → 248
      G-patch; G-patch domain

    3. NM_001042959.3 → NP_001036424.1  Spf45, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL39, Q7PL82
      Conserved Domains (2) summary
      cd12647
      Location:267 → 362
      RRM_UHM_SPF45; RNA recognition motif in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
      pfam01585
      Location:169 → 208
      G-patch; G-patch domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7PL81 Q7PL81
    Q7PL82 Q7PL82
    Q7PL83 Q7PL83
    Q8SYI1 Q8SYI1

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