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    Aplip1 APPL-interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53472, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aplip1provided by FlyBase
    Official Full Name
    APPL-interacting protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0040281
    Locus tag
    Dmel_CG1200
    See related
    AllianceGenome:FB:FBgn0040281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aplilp1; Aplip; Aplip-1; aplip1; APLIP1; CG1200; Dmel\CG1200; dp1; E(Khc)ek4; ek4; Ek4; EK4; JIP-1; jip1; Jip1; JIP1; Jip1/2; SP512
    Summary
    Enables MAP-kinase scaffold activity; kinesin binding activity; and protein kinase binding activity. Involved in axonal transport; regulation of JNK cascade; and regulation of terminal button organization. Located in axon. Is expressed in several structures, including Malpighian tubule primordium; amnioserosa; amnioserosa primordium; ganglia; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1) and MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Aplip1 in Genome Data Viewer
    Location:
    61F3-61F3; 3-0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1196317..1199339)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1196317..1199339)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tryptophan hydroxylase neuronal Neighboring gene Lysozyme X Neighboring gene multiple wing hairs Neighboring gene meep Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aplip1, the Drosophila homolog of JIP1, regulates myonuclear positioning and muscle stability. Auld AL, et al. J Cell Sci, 2018 Mar 16. PMID 29487176
    2. Control of a kinesin-cargo linkage mechanism by JNK pathway kinases. Horiuchi D, et al. Curr Biol, 2007 Aug 7. PMID 17658258, Free PMC Article
    3. RIM-binding protein couples synaptic vesicle recruitment to release sites. Petzoldt AG, et al. J Cell Biol, 2020 Jul 6. PMID 32369542, Free PMC Article
    4. APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila. Horiuchi D, et al. Curr Biol, 2005 Dec 6. PMID 16332540, Free PMC Article
    5. Transient active zone remodeling in the Drosophila mushroom body supports memory. Turrel O, et al. Curr Biol, 2022 Nov 21. PMID 36327980

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aplip1 localizes to the myotendinous junction and has genetically separable roles in myonuclear positioning and muscle stability.
      Title: Aplip1, the Drosophila homolog of JIP1, regulates myonuclear positioning and muscle stability.
    2. The authors show in atomic detail that RBP C-terminal Src-homology 3 domains bind a proline-rich (PxxP) motif of Aplip1/JIP1 with submicromolar affinity.
      Title: A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones.
    3. APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila.
      Title: APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables JUN kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables JUN kinase binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables MAP-kinase scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonal transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of JNK cascade IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    APPL-interacting protein 1
    Names
    APP-like protein interacting protein 1
    Aplip1-PA
    Aplip1-PB
    CG1200-PA
    CG1200-PB
    JNK interacting protein-1
    c-Jun N-terminal kinase (JNK)-interacting protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1196317..1199339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167856.3 → NP_728573.1  APPL-interacting protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728573.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGG5, Q9NH69, Q9W0K0
      Related
      FBpp0072523
      Conserved Domains (2) summary
      cd11801
      Location:275 → 329
      SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
      cd01212
      Location:343 → 490
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    2. NM_167857.4 → NP_728574.1  APPL-interacting protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728574.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W0K0
      Related
      FBpp0072522
      Conserved Domains (2) summary
      cd11801
      Location:268 → 322
      SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
      cd01212
      Location:336 → 483
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0K0.2 Q9W0K0

    Gene LinkOut

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