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    MME1 Mitochondrial Magnesium Exporter 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MME1provided by FlyBase
    Official Full Name
    Mitochondrial Magnesium Exporter 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031881
    Locus tag
    Dmel_CG3476
    See related
    AllianceGenome:FB:FBgn0031881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3476; Dmel\CG3476; dMme1
    Summary
    Enables magnesium ion transmembrane transporter activity. Involved in intracellular magnesium ion homeostasis and magnesium ion export from mitochondrion. Is active in mitochondrial inner membrane. Is expressed in several structures, including adult head; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MME1 in Genome Data Viewer
    Location:
    27D4-27D5; 2-24 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7027526..7028959)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7027526..7028959)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene GART trifunctional enzyme Neighboring gene Pupal cuticle protein Neighboring gene uncharacterized protein Neighboring gene Rab30 Neighboring gene caper Neighboring gene milton

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel Drosophila mitochondrial carrier protein acts as a Mg(2+) exporter in fine-tuning mitochondrial Mg(2+) homeostasis. Cui Y, et al. Biochim Biophys Acta, 2016 Jan. PMID 26462626
    2. Widespread adaptive evolution of Drosophila genes with sex-biased expression. Pröschel M, et al. Genetics, 2006 Oct. PMID 16951084, Free PMC Article
    3. The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3. Gajan A, et al. Epigenetics Chromatin, 2016. PMID 26848313, Free PMC Article
    4. Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study. Cuesta-Astroz Y, et al. Front Genet, 2021. PMID 34394179, Free PMC Article
    5. Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function. Barnes VL, et al. BMC Biochem, 2010 Jul 9. PMID 20618965, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyl carnitine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnitine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular magnesium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular magnesium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in magnesium ion export from mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in magnesium ion export from mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial inner membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial magnesium exporter 1
    Names
    CG3476-PA
    MME1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7027526..7028959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135249.3 → NP_609093.1  mitochondrial magnesium exporter 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VM51
      UniProtKB/TrEMBL
      A0APZ9, C0MKK1
      Related
      FBpp0079017
      Conserved Domains (1) summary
      pfam00153
      Location:10 → 107
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM51.1 Q9VM51

    Gene LinkOut

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