U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    su(f) suppressor of forked [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354994, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    su(f)provided by FlyBase
    Official Full Name
    suppressor of forkedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003559
    Locus tag
    Dmel_CG17170
    See related
    AllianceGenome:FB:FBgn0003559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    19; 28; 29; 3-DES; 3DES; CG17170; CstF-77; Cstf77; CstF77; Dmel\CG17170; EC235; l(1)20Eb; l(1)3DES; l(1)EC235; l(1)G0393; l(1)R-9-18; l(1)su(f); l(1)X1; l(1)X3; l3DES; R-9-18; R9-18; Su(f); su-f; SU-f; su[+]-f
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in RNA 3'-end processing. Part of mRNA cleavage stimulating factor complex. Is expressed in adult head; eye disc anterior to the morphogenetic furrow; imaginal disc; and organism. Orthologous to human CSTF3 (cleavage stimulation factor subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See su(f) in Genome Data Viewer
    Location:
    20F4-20F4; 1-66 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (23096771..23101431)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) XHet NW_001848859.1 (75589..80249)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43480 Neighboring gene pseudo Neighboring gene (A+T)-stretch binding protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutations at the suppressor of forked locus increase the accumulation of gypsy-encoded transcripts in Drosophila melanogaster. Parkhurst SM, et al. Mol Cell Biol, 1986 Jun. PMID 3023926, Free PMC Article
    2. Lack of correlation between interspecific divergence and intraspecific polymorphism at the suppressor of forked region in Drosophila melanogaster and Drosophila simulans. Langley CH, et al. Proc Natl Acad Sci U S A, 1993 Mar 1. PMID 8095333, Free PMC Article
    3. Molecular and cytogenetic analysis of the heterochromatin-euchromatin junction region of the Drosophila melanogaster X chromosome using cloned DNA sequences. Yamamoto MT, et al. Genetics, 1990 Aug. PMID 2118871, Free PMC Article
    4. The Induction of OOgonial Crossing over in Drosophila Melanogaster. Whittinghill M. Genetics, 1938 May. PMID 17246889, Free PMC Article
    5. A 1.5 kb repeat sequence flanks the suppressor of forked gene at the euchromatin-heterochromatin boundary of the Drosophila melanogaster X chromosome. Tudor M, et al. Genet Res, 1996 Dec. PMID 9062076

    See all (175) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. su(f) is required for the cleavage of pre-mRNA during mRNA 3' end formation
      Title: Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage stimulating factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    suppressor of forked
    Names
    CG17170-PE
    CG17170-PF
    CG17170-PG
    lethal3Des
    section 19
    section 28
    section 29
    su(f)-PE
    su(f)-PF
    su(f)-PG

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      23096771..23101431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001111010.3 → NP_001104480.2  suppressor of forked, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104480.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25991
      Conserved Domains (3) summary
      smart00386
      Location:48 → 78
      HAT; HAT (Half-A-TPR) repeats
      COG0457
      Location:245 → 519
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      pfam05843
      Location:376 → 650
      Suf; Suppressor of forked protein (Suf)

    2. NM_001015241.4 → NP_001015241.3  suppressor of forked, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015241.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A023GQK0, A8Y5B4, A8Y5B5, P25991, Q24539, Q5BI40, Q6NKM3, Q7PLW9, Q7PLX0, Q7PLX1, Q8MZI2, Q9W5P7
      Conserved Domains (3) summary
      smart00386
      Location:48 → 78
      HAT; HAT (Half-A-TPR) repeats
      COG5107
      Location:19 → 550
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      pfam05843
      Location:408 → 682
      Suf; Suppressor of forked protein (Suf)

    3. NM_001111009.4 → NP_001104479.1  suppressor of forked, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104479.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25991
      Conserved Domains (3) summary
      smart00386
      Location:48 → 78
      HAT; HAT (Half-A-TPR) repeats
      COG0457
      Location:245 → 519
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      pfam05843
      Location:376 → 650
      Suf; Suppressor of forked protein (Suf)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25991.2 P25991

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous