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    CG17292 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34152, updated on 9-Dec-2024

    Summary

    Official Symbol
    CG17292provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032029
    Locus tag
    Dmel_CG17292
    See related
    AllianceGenome:FB:FBgn0032029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17292
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic dorsal epidermis; embryonic ventral epidermis; and embryonic/larval oenocyte. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CG17292 in Genome Data Viewer
    Location:
    29B2-29B2; 2-31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8370454..8374250)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8370454..8374250)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 8 Neighboring gene Protein phosphatase 2A at 29B Neighboring gene antisense RNA:CR45341 Neighboring gene WD repeat domain 82 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity  
    enables lipase activity  
    enables triacylglycerol lipase activity  
    Process Evidence Code Pubs
    involved_in lipid catabolic process  
    involved_in lipid metabolic process  
    Component Evidence Code Pubs
    located_in cytosol PubMed 
    is_active_in extracellular space  

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG17292-PA
    CG17292-PB
    CG17292-PC
    CG17292-PD
    lipase
    NP_001285749.1
    NP_001285750.1
    NP_609216.1
    NP_723380.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8370454..8374250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298821.1 → NP_001285750.1  uncharacterized protein Dmel_CG17292, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3Z8
      Conserved Domains (1) summary
      cd00707
      Location:23 → 303
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    2. NM_001298820.1 → NP_001285749.1  uncharacterized protein Dmel_CG17292, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3Z8
      Conserved Domains (1) summary
      cd00707
      Location:23 → 303
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    3. NM_164811.3 → NP_723380.1  uncharacterized protein Dmel_CG17292, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3Z8
      Related
      FBpp0079264
      Conserved Domains (1) summary
      cd00707
      Location:23 → 303
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    4. NM_135372.4 → NP_609216.1  uncharacterized protein Dmel_CG17292, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3Z8
      Related
      FBpp0079265
      Conserved Domains (1) summary
      cd00707
      Location:23 → 303
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
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