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    Blos2 Biogenesis of lysosome-related organelles complex 1, subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Blos2provided by FlyBase
    Official Full Name
    Biogenesis of lysosome-related organelles complex 1, subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036118
    Locus tag
    Dmel_CG14145
    See related
    AllianceGenome:FB:FBgn0036118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    blos2; BLOS2; CG14145; DmBlos2; Dmel\CG14145; NP_648427
    Summary
    Enables protein homodimerization activity. Involved in autophagosome-lysosome fusion. Predicted to be part of BLOC-1 complex; BORC complex; and gamma-tubulin complex. Orthologous to human BLOC1S2 (biogenesis of lysosomal organelles complex 1 subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Blos2 in Genome Data Viewer
    Location:
    68A3-68A3; 3-34 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11061571..11062215)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11054671..11055315)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45119 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Suppressor of Under-Replication

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity. Mullin AP, et al. J Neurosci, 2015 Jan 7. PMID 25568125, Free PMC Article
    2. Decoding the nexus: branched-chain amino acids and their connection with sleep, circadian rhythms, and cardiometabolic health. Li H, et al. Neural Regen Res, 2025 May 1. PMID 39075896, Free PMC Article
    3. A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1). Rodriguez-Fernandez IA, et al. J Inherit Metab Dis, 2009 Apr. PMID 19083121, Free PMC Article
    4. Pallidin function in Drosophila surface glia regulates sleep and is dependent on amino acid availability. Li H, et al. Cell Rep, 2023 Sep 26. PMID 37682712
    5. Drosophila Arl8 is a general positive regulator of lysosomal fusion events. Boda A, et al. Biochim Biophys Acta Mol Cell Res, 2019 Apr. PMID 30590083

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of BLOC-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BLOC-1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of BORC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    biogenesis of lysosome-related organelles complex 1, subunit 2
    Names
    BLOC-1 subunit 2
    Blos2-PA
    CG14145-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11061571..11062215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140170.2 → NP_648427.1  biogenesis of lysosome-related organelles complex 1, subunit 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTE0
      UniProtKB/TrEMBL
      A0A1B2AKW7
      Related
      FBpp0075932
      Conserved Domains (1) summary
      pfam10046
      Location:51 → 145
      BLOC1_2; Biogenesis of lysosome-related organelles complex-1 subunit 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTE0.2 Q9VTE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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