U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    l(2)05714 lethal (2) 05714 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46066, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    l(2)05714provided by FlyBase
    Official Full Name
    lethal (2) 05714provided by FlyBase
    Primary source
    FLYBASE:FBgn0010607
    Locus tag
    Dmel_CG8886
    See related
    AllianceGenome:FB:FBgn0010607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8886; Dmel\CG8886; l(2)05715
    Summary
    Is expressed in several structures, including central brain primordium; embryonic/larval esophageal visceral muscle; ganglia; mesoderm; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See l(2)05714 in Genome Data Viewer
    Location:
    25B5-25B5; 2-14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4970135..4973921, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4970135..4973921, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit i Neighboring gene Synthesis of cytochrome c oxidase Neighboring gene RNA polymerase I and III subunit C Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene GDP-mannose 4,6-dehydratase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. KSR, a novel protein kinase required for RAS signal transduction. Therrien M, et al. Cell, 1995 Dec 15. PMID 8521512
    2. A small genomic region containing several loci required for gastrulation in Drosophila. Mathew SJ, et al. PLoS One, 2009 Oct 13. PMID 19823683, Free PMC Article
    3. Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Brodsky MH, et al. Mol Cell Biol, 2004 Feb. PMID 14729967, Free PMC Article
    4. A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity. Baumbach J, et al. Cell Metab, 2014 Feb 4. PMID 24506874
    5. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Asha H, et al. Genetics, 2003 Jan. PMID 12586708, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lethal (2) 05714
    Names
    CG8886-PA
    CG8886-PB
    CG8886-PC
    l(2)05714-PA
    l(2)05714-PB
    l(2)05714-PC
    NP_001260062.1
    • unusual splice
    NP_652033.3
    • unusual splice

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4970135..4973921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273133.2 → NP_001260062.1  lethal (2) 05714, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKK9, Q7K2E7, Q9VMX2

    2. NM_143776.4 → NP_652033.3  lethal (2) 05714, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652033.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKK9, Q7K2E7, Q9VMX2

    3. NM_164605.3 → NP_723031.1  lethal (2) 05714, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723031.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKK9, Q8IPL4
      Related
      FBpp0078687
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPL4 Q8IPL4
    Q9VMX2 Q9VMX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools