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    whd withered [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36109, updated on 27-Dec-2024

    Summary

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    Official Symbol
    whdprovided by FlyBase
    Official Full Name
    witheredprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261862
    Locus tag
    Dmel_CG12891
    See related
    AllianceGenome:FB:FBgn0261862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH27794; CG12891; cpt1; Cpt1; CPT1; CPTI; dCPT1; Dmel\CG12891; gh27794
    Summary
    Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in carnitine metabolic process and fatty acid metabolic process. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; fat body; and ganglia. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency; hereditary spastic paraplegia 73; and lipid metabolism disorder. Orthologous to several human genes including CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See whd in Genome Data Viewer
    Location:
    47A9-47A11; 2-62 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10469473..10478567, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6356978..6366072, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene G protein alpha subunit o Neighboring gene Cytochrome P450 49a1 Neighboring gene Chromatin assembly factor 1, p105 subunit Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45134 Neighboring gene translin Neighboring gene Peflin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues. Price NT, et al. J Biol Chem, 2010 Mar 12. PMID 20061394, Free PMC Article
    2. Sequencing and functional expression of the malonyl-CoA-sensitive carnitine palmitoyltransferase from Drosophila melanogaster. Jackson VN, et al. Biochem J, 1999 Aug 1. PMID 10417309, Free PMC Article
    3. Glial β-oxidation regulates Drosophila energy metabolism. Schulz JG, et al. Sci Rep, 2015 Jan 15. PMID 25588812, Free PMC Article
    4. Transportin-serine/arginine-rich (Tnpo-SR) proteins are necessary for proper lipid storage in the Drosophila fat body. Nagle C, et al. Biochem Biophys Res Commun, 2022 Mar 12. PMID 35104661
    5. Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43. Manzo E, et al. Front Mol Neurosci, 2018. PMID 29904341, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alternative splicing that specifically affects a structurally crucial region of the protein is an important mechanism through which functional diversity of CPT1 kinetics is generated from the single gene that occurs in insects
      Title: Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-palmitoyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    withered
    Names
    CG12891-PA
    CG12891-PB
    CG12891-PC
    CG12891-PD
    carnitin-palmitoyl transferase-I
    carnitine PalmitoylTransferase 1
    carnitine-O-palmitoyltransferase
    mitochondrial carnitine palamitoyltransferase I
    mitochondrial carnitine palmitoyltransferase I
    whd-PA
    whd-PB
    whd-PC
    whd-PD
    NP_001163111.1
    NP_001163112.1
    NP_523685.2
    NP_724940.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10469473..10478567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078961.4 → NP_523685.2  withered, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523685.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQH9
      Related
      FBpp0087399
      Conserved Domains (2) summary
      pfam00755
      Location:171 → 757
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 45
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    2. NM_001169640.2 → NP_001163111.1  withered, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163111.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3K9
      Conserved Domains (2) summary
      pfam00755
      Location:171 → 759
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 45
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    3. NM_165777.3 → NP_724940.1  withered, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQH9
      Related
      FBpp0087400
      Conserved Domains (2) summary
      pfam00755
      Location:171 → 757
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 45
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    4. NM_001169641.2 → NP_001163112.1  withered, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163112.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3K9
      Conserved Domains (2) summary
      pfam00755
      Location:171 → 759
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 45
      CPT_N; Carnitine O-palmitoyltransferase N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQH9 Q7JQH9
    Q9V3K9 Q9V3K9

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