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    Fkbp59 FK506-binding protein 59kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47762, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Fkbp59provided by FlyBase
    Official Full Name
    FK506-binding protein 59kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029174
    Locus tag
    Dmel_CG4535
    See related
    AllianceGenome:FB:FBgn0029174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.161; CG4535; dFKBP4; dFKBP59; Dmel\CG4535; fkbp59; FKBP59; FKBP59-bp1; l(2)k00424; l(2)k09010
    Summary
    Predicted to enable FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in detection of light stimulus involved in visual perception and regulation of calcium ion transport. Part of inaD signaling complex. Is expressed in several structures, including adult head; embryonic/larval crystal cell; embryonic/larval garland cell; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP4 (FKBP prolyl isomerase 4) and FKBP5 (FKBP prolyl isomerase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fkbp59 in Genome Data Viewer
    Location:
    30E1-30E1; 2-37 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9888005..9890119)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9888005..9890119)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor alpha6 Neighboring gene long non-coding RNA:CR43766 Neighboring gene long non-coding RNA:CR44701 Neighboring gene mitochondrial DNA helicase Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene U snoRNA host gene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and embryonic expression of dFKBP59, a novel Drosophila FK506-binding protein. Zaffran S. Gene, 2000 Apr 4. PMID 10767531
    2. Control of Alzheimer's amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila. Sanokawa-Akakura R, et al. PLoS One, 2010 Jan 13. PMID 20084280, Free PMC Article
    3. Regulation of Drosophila TRPL channels by immunophilin FKBP59. Goel M, et al. J Biol Chem, 2001 Oct 19. PMID 11514552
    4. Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. Ghartey-Kwansah G, et al. BMC Dev Biol, 2018 Mar 27. PMID 29587629, Free PMC Article
    5. shutdown is a component of the Drosophila piRNA biogenesis machinery. Preall JB, et al. RNA, 2012 Aug. PMID 22753781, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FK506 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of light stimulus involved in visual perception IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inaD signaling complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FK506-binding protein 59kD
    Names
    CG4535-PA
    CG4535-PB
    FK506-binding protein FKBP59
    Fkbp59-PA
    Fkbp59-PB
    NP_001285784.1
    NP_524895.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9888005..9890119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298855.1 → NP_001285784.1  FK506-binding protein 59kD, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285784.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4N1, Q9VL78
      UniProtKB/TrEMBL
      X2J5E8
      Conserved Domains (7) summary
      TIGR03516
      Location:124 → 233
      ppisom_GldI; peptidyl-prolyl isomerase, gliding motility-associated
      sd00006
      Location:252 → 280
      TPR; TPR repeat [structural motif]
      cd15830
      Location:252 → 390
      BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
      pfam00254
      Location:25 → 117
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:331 → 364
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:299 → 362
      TPR_11; TPR repeat
      pfam13424
      Location:252 → 329
      TPR_12; Tetratricopeptide repeat

    2. NM_080156.4 → NP_524895.2  FK506-binding protein 59kD, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524895.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4N1, Q9VL78
      UniProtKB/TrEMBL
      X2J5E8
      Related
      FBpp0079468
      Conserved Domains (7) summary
      TIGR03516
      Location:124 → 233
      ppisom_GldI; peptidyl-prolyl isomerase, gliding motility-associated
      sd00006
      Location:252 → 280
      TPR; TPR repeat [structural motif]
      cd15830
      Location:252 → 390
      BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
      pfam00254
      Location:25 → 117
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:331 → 364
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:299 → 362
      TPR_11; TPR repeat
      pfam13424
      Location:252 → 329
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL78.1 Q9VL78
    X2J5E8 X2J5E8

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