IFI27 interferon alpha inducible protein 27 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IFI27provided by HGNC
Official Full Name: interferon alpha inducible protein 27provided by HGNC
Primary source: HGNC:HGNC:5397
See related: Ensembl:ENSG00000165949 MIM:600009; AllianceGenome:HGNC:5397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P27; ISG12; FAM14D; ISG12A
Summary: Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and lamin binding activity. Involved in several processes, including defense response to symbiont; protein K48-linked ubiquitination; and pyroptotic inflammatory response. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of protein export from nucleus. Located in mitochondrial membrane and nuclear inner membrane. Is active in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in stomach (RPKM 224.1), spleen (RPKM 211.7) and 21 other tissues See more
Orthologs: all
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Genomic context

Location:: 14q32.12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (94105894..94116690)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (88338053..88343998)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (94577082..94583027)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrative bulk and single-cell transcriptome profiling analysis reveals IFI27 as a novel interferon-stimulated gene in dengue.
Title: Integrative bulk and single-cell transcriptome profiling analysis reveals IFI27 as a novel interferon-stimulated gene in dengue.
Behcet syndrome: The disturbed balance between anti- (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions.
Title: Behçet syndrome: The disturbed balance between anti- (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions.
IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study.
Title: IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study.
Knockdown of NEAT1 restricts dengue virus replication by augmenting interferon alpha-inducible protein 27 via the RIG-I pathway.
Title: Knockdown of NEAT1 restricts dengue virus replication by augmenting interferon alpha-inducible protein 27 via the RIG-I pathway.
MiR-942-5p targeting the IFI27 gene regulates HCT-8 cell apoptosis via a TRAIL-dependent pathway during the early phase of Cryptosporidium parvum infection.
Title: MiR-942-5p targeting the IFI27 gene regulates HCT-8 cell apoptosis via a TRAIL-dependent pathway during the early phase of Cryptosporidium parvum infection.
ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF.
Title: ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF.
PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p.
Title: PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p.
Interferon alpha-inducible protein 27 (IFI27) is a prognostic marker for pancreatic cancer based on comprehensive bioinformatics analysis.
Title: Interferon alpha-inducible protein 27 (IFI27) is a prognostic marker for pancreatic cancer based on comprehensive bioinformatics analysis.
IFI27 may predict and evaluate the severity of respiratory syncytial virus infection in preterm infants.
Title: IFI27 may predict and evaluate the severity of respiratory syncytial virus infection in preterm infants.
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/beta-catenin signaling pathway.
Title: The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 and the viral protein Tat modulate the expression of interferon, alpha-inducible protein 27 (IFI27) in immature dendritic cells and monocyte-derived macrophages	PubMed
	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFI27, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed
Vpr	vpr	HIV-1 Vpr upregulates the gene expression of IFI27 in human monocyte-derived dendritic cells	PubMed
	vpr	HIV-1 Vpr upregulates the gene expression of IFI27 in human monocyte-derived macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables lamin binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation by host of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K48-linked ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyroptotic inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon alpha-inducible protein 27, mitochondrial

Names: 2310061N23Rik; ISG12(a); interferon alpha-induced 11.5 kDa protein; interferon-stimulated gene 12a protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130080.3 → NP_001123552.1 interferon alpha-inducible protein 27, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_001123552.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). This variant represents an allele commonly found in the human population and corresponds to the allele present in the GRC reference assembly. Variants 1, 3, 5, 11 and 12 encode the same isoform (1).

Source sequence(s)

BN000227

UniProtKB/Swiss-Prot

A0A087WZF8, A8K0H0, P40305, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1

UniProtKB/TrEMBL

A0A348GSI0

Related

ENSP00000483498.1, ENST00000621160.5

Conserved Domains (1) summary

pfam06140
Location:40 → 116

Ifi-6-16; Interferon-induced 6-16 family
NM_001288952.2 → NP_001275881.1 interferon alpha-inducible protein 27, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_001275881.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an additional exon in the 5' UTR, compared to variant 1. This variant corresponds to the allele present in the GRC reference assembly. Variants 1, 3 and 5, 11 and 12 encode the same isoform (1).

Source sequence(s)

AU103232, BC015492, BF971643

UniProtKB/Swiss-Prot

A0A087WZF8, A8K0H0, P40305, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1

UniProtKB/TrEMBL

A0A348GSI0

Related

ENSP00000477753.1, ENST00000616764.5

Conserved Domains (1) summary

pfam06140
Location:40 → 116

Ifi-6-16; Interferon-induced 6-16 family
NM_001288956.2 → NP_001275885.1 interferon alpha-inducible protein 27, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_001275885.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, compared to variant 1. This variant corresponds to the allele present in the GRC reference assembly. Variants 1, 3 and 5, 11 and 12 encode the same isoform (1).

Source sequence(s)

BG483267, BU688913

UniProtKB/Swiss-Prot

A0A087WZF8, A8K0H0, P40305, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1

UniProtKB/TrEMBL

A0A348GSI0

Conserved Domains (1) summary

pfam06140
Location:40 → 116

Ifi-6-16; Interferon-induced 6-16 family
NM_001288959.2 → NP_001275888.1 interferon alpha-inducible protein 27, mitochondrial isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks an internal exon in the 5' region which results in translation initiation at a downstream AUG codon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1. This variant corresponds to the allele present in the GRC reference assembly.

Source sequence(s)

BU928223

UniProtKB/TrEMBL

A0A087WZF8

Related

ENSP00000482635.1, ENST00000618863.1

Conserved Domains (1) summary

pfam06140
Location:2 → 73

Ifi-6-16; Interferon-induced 6-16 family
NM_001366993.1 → NP_001353922.1 interferon alpha-inducible protein 27, mitochondrial isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. This variant represents an allele commonly found in the human population and corresponds to the allele present in the GRC reference assembly. Variants 1, 3, 5, 11 and 12 encode the same isoform (1).

Source sequence(s)

AL121838, KF573698

Consensus CDS

CCDS32148.1

UniProtKB/Swiss-Prot

A0A087WZF8, A8K0H0, P40305, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1

UniProtKB/TrEMBL

A0A348GSI0

Related

ENSP00000483430.1, ENST00000612813.4

Conserved Domains (1) summary

pfam06140
Location:40 → 116

Ifi-6-16; Interferon-induced 6-16 family
NM_001366994.1 → NP_001353923.1 interferon alpha-inducible protein 27, mitochondrial isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. This variant represents an allele commonly found in the human population and corresponds to the allele present in the GRC reference assembly. Variants 1, 3, 5, 11 and 12 encode the same isoform (1).

Source sequence(s)

AL079302, AL121838, KF573698

Consensus CDS

CCDS32148.1

UniProtKB/Swiss-Prot

A0A087WZF8, A8K0H0, P40305, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1

UniProtKB/TrEMBL

A0A348GSI0

Conserved Domains (1) summary

pfam06140
Location:40 → 116

Ifi-6-16; Interferon-induced 6-16 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

94105894..94116690

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047431346.1 → XP_047287302.1 interferon alpha-inducible protein 27, mitochondrial isoform X1
XM_047431349.1 → XP_047287305.1 interferon alpha-inducible protein 27, mitochondrial isoform X2

UniProtKB/Swiss-Prot

A0A087WZF8, A8K0H0, P40305, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

1219393..1231252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328975.1 → XP_054184950.1 interferon alpha-inducible protein 27, mitochondrial isoform X2

UniProtKB/Swiss-Prot

A0A087WZF8, A8K0H0, P40305, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1
XM_054328973.1 → XP_054184948.1 interferon alpha-inducible protein 27, mitochondrial isoform X1
XM_054328974.1 → XP_054184949.1 interferon alpha-inducible protein 27, mitochondrial isoform X2

UniProtKB/Swiss-Prot

A0A087WZF8, A8K0H0, P40305, Q53YA6, Q6IEC1, Q7Z5R0, Q7Z5R1, Q7Z5R2, Q96BK3, Q9H4B1

Alternate T2T-CHM13v2.0

Genomic

NC_060938.1 Alternate T2T-CHM13v2.0

Range

88338053..88343998

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001288954.2: Suppressed sequence

Description

NM_001288954.2: This RefSeq was removed because the 9-nt deletion in the transcript, resulting in a 3-aa deletion in the protein, is not present in the reference genome.
NM_001288957.2: Suppressed sequence

Description

NM_001288957.2: This RefSeq was removed because the 9-nt deletion in the transcript, resulting in a 3-aa deletion in the protein, is not present in the reference genome.
NM_001288958.2: Suppressed sequence

Description

NM_001288958.2: This RefSeq was removed because the 9-nt deletion in the transcript, resulting in a 3-aa deletion in the protein, is not present in the reference genome.
NM_001288960.2: Suppressed sequence

Description

NM_001288960.2: This RefSeq was removed because the 9-nt deletion in the transcript, resulting in the use of a downstream start codon, is not present in the reference genome.
NM_001288995.2: Suppressed sequence

Description

NM_001288995.2: This RefSeq was removed because the 9-nt deletion in the transcript, resulting in a 3-aa deletion in the protein, is not present in the reference genome.
NM_005532.5: Suppressed sequence

Description

NM_005532.5: This RefSeq was removed because the 9-nt deletion in the transcript, resulting in a 3-aa deletion in the protein, is not present in the reference genome.