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    Kmt5b lysine methyltransferase 5B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kmt5bprovided by RGD
    Official Full Name
    lysine methyltransferase 5Bprovided by RGD
    Primary source
    RGD:1311637
    See related
    EnsemblRapid:ENSRNOG00000016790 AllianceGenome:RGD:1311637
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Suv420h1
    Summary
    Predicted to enable S-adenosyl-L-methionine binding activity; chromatin binding activity; and histone H4K20 methyltransferase activity. Predicted to be involved in DNA repair; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to be located in condensed chromosome, centromeric region and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 51. Orthologous to human KMT5B (lysine methyltransferase 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 174.3), Lung (RPKM 145.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kmt5b in Genome Data Viewer
    Location:
    1q43
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210429672..210479042)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201000444..201049819)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219000844..219050211)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 11 open reading frame 24 Neighboring gene family with sequence similarity 18, member B, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) 2 Neighboring gene choline kinase alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. Wu H, et al. FEBS Lett, 2013 Nov 29. PMID 24396869
    2. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Bromberg KD, et al. Nat Chem Biol, 2017 Mar. PMID 28114273
    3. A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases. Southall SM, et al. Nucleic Acids Res, 2014 Jan. PMID 24049080, Free PMC Article
    4. Modulation of p53 function by SET8-mediated methylation at lysine 382. Shi X, et al. Mol Cell, 2007 Aug 17. PMID 17707234, Free PMC Article
    5. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Schotta G, et al. Genes Dev, 2004 Jun 1. PMID 15145825, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-adenosyl-L-methionine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H4K20 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K20 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K20 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K20 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H4K20 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K20me methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of isotype switching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of isotype switching ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase KMT5B
    Names
    [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B
    [histone H4]-lysine20 N-methyltransferase KMT5B
    histone-lysine N-methyltransferase SUV420H1
    lysine (K)-specific methyltransferase 5B
    lysine-specific methyltransferase 5B
    su(var)4-20 homolog 1
    suppressor of variegation 4-20 homolog 1
    suv4-20h1
    NP_001101982.1
    XP_038939567.1
    XP_038939570.1
    XP_038939576.1
    XP_038939584.1
    XP_038939588.1
    XP_038939595.1
    XP_038939599.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108512.2 → NP_001101982.1  histone-lysine N-methyltransferase KMT5B

      See identical proteins and their annotated locations for NP_001101982.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P0C2N5
      UniProtKB/TrEMBL
      A6HYL9
      Conserved Domains (1) summary
      cd19184
      Location:192 → 335
      SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210429672..210479042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083667.2 → XP_038939595.1  histone-lysine N-methyltransferase KMT5B isoform X4

      Conserved Domains (1) summary
      cl40432
      Location:192 → 325
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

    2. XM_039083648.2 → XP_038939576.1  histone-lysine N-methyltransferase KMT5B isoform X2

      UniProtKB/TrEMBL
      A0A8I6G6N5, A6HYM0
      Related
      ENSRNOP00000080478.1, ENSRNOT00000102948.2
      Conserved Domains (1) summary
      cd19184
      Location:169 → 312
      SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

    3. XM_039083671.2 → XP_038939599.1  histone-lysine N-methyltransferase KMT5B isoform X5

      Conserved Domains (1) summary
      cl40432
      Location:192 → 274
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

    4. XM_039083639.2 → XP_038939567.1  histone-lysine N-methyltransferase KMT5B isoform X1

      UniProtKB/Swiss-Prot
      P0C2N5
      UniProtKB/TrEMBL
      A6HYL9
      Related
      ENSRNOP00000022486.5, ENSRNOT00000022486.8
      Conserved Domains (1) summary
      cd19184
      Location:192 → 335
      SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

    5. XM_039083642.1 → XP_038939570.1  histone-lysine N-methyltransferase KMT5B isoform X1

      UniProtKB/Swiss-Prot
      P0C2N5
      UniProtKB/TrEMBL
      A6HYL9
      Conserved Domains (1) summary
      cd19184
      Location:192 → 335
      SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

    6. XM_039083660.2 → XP_038939588.1  histone-lysine N-methyltransferase KMT5B isoform X3

    7. XM_039083656.2 → XP_038939584.1  histone-lysine N-methyltransferase KMT5B isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C2N5.1 GenPept UniProtKB/Swiss-Prot:P0C2N5

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