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    Arhgap19 Rho GTPase activating protein 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgap19provided by RGD
    Official Full Name
    Rho GTPase activating protein 19provided by RGD
    Primary source
    RGD:1593044
    See related
    EnsemblRapid:ENSRNOG00000048166 AllianceGenome:RGD:1593044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ARHGAP19 (Rho GTPase activating protein 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 73.1), Spleen (RPKM 72.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap19 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (250519703..250566705, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (240571554..240617361, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (261015083..261051515, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ligand dependent nuclear receptor corepressor Neighboring gene slit guidance ligand 1 Neighboring gene uncharacterized LOC134485238 Neighboring gene uncharacterized LOC102553733 Neighboring gene FRAT regulator of WNT signaling pathway 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401120.1 → NP_001388049.1  rho GTPase-activating protein 19

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ACN1, M0R5V4
      Related
      ENSRNOP00000064785.2, ENSRNOT00000071417.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      250519703..250566705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101420.2 → XP_038957348.1  rho GTPase-activating protein 19 isoform X5

      Conserved Domains (1) summary
      cd04392
      Location:18 → 225
      RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

    2. XM_039101419.2 → XP_038957347.1  rho GTPase-activating protein 19 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACN1
      Conserved Domains (1) summary
      cd04392
      Location:113 → 320
      RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

    3. XM_063273204.1 → XP_063129274.1  rho GTPase-activating protein 19 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ACN1

    4. XM_063273199.1 → XP_063129269.1  rho GTPase-activating protein 19 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ACN1
      Related
      ENSRNOP00000089901.2, ENSRNOT00000097202.2

    5. XM_017590380.2 → XP_017445869.1  rho GTPase-activating protein 19 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ACN1

    6. XM_063273187.1 → XP_063129257.1  rho GTPase-activating protein 19 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACN1
      Related
      ENSRNOP00000112280.1, ENSRNOT00000152733.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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