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    Rai14 retinoic acid induced 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294804, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rai14provided by RGD
    Official Full Name
    retinoic acid induced 14provided by RGD
    Primary source
    RGD:1305942
    See related
    EnsemblRapid:ENSRNOG00000028872 AllianceGenome:RGD:1305942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Orthologous to human RAI14 (retinoic acid induced 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 135.6), Spleen (RPKM 86.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rai14 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (61273439..61411141, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (59546284..59682687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (60546083..60684365, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L40, pseudogene 1 Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit, pseudogene 1 Neighboring gene uncharacterized LOC120100740 Neighboring gene uncharacterized LOC103691483 Neighboring gene uncharacterized LOC134485720

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rai14 (retinoic acid induced protein 14) is involved in regulating f-actin dynamics at the ectoplasmic specialization in the rat testis*. Qian X, et al. PLoS One, 2013. PMID 23565266, Free PMC Article
    2. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rai14 is involved in the re-organization of actin filaments in Sertoli cells during the epithelial cycle, participating in conferring spermatid polarity and cell adhesion in the testis.
      Title: Rai14 (retinoic acid induced protein 14) is involved in regulating f-actin dynamics at the ectoplasmic specialization in the rat testis*.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankycorbin
    Names
    ankyrin repeat and coiled-coil structure-containing protein
    retinoic acid-induced protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011947.2 → NP_001011947.1  ankycorbin isoform 2

      See identical proteins and their annotated locations for NP_001011947.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZN94, A6KJS6
      Related
      ENSRNOP00000049295.5, ENSRNOT00000046215.7
      Conserved Domains (6) summary
      cd00204
      Location:81 → 205
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05046
      Location:486 → 531
      Img2; Mitochondrial large subunit ribosomal protein (Img2)
      pfam12796
      Location:123 → 215
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:52 → 83
      ANK; ANK repeat [structural motif]
      cl19219
      Location:559 → 632
      DUF342; Protein of unknown function (DUF342)
      cl21478
      Location:755 → 862
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. NM_001399209.1 → NP_001386138.1  ankycorbin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q5U312
      UniProtKB/TrEMBL
      A0A8I5ZN94
      Related
      ENSRNOP00000048063.4, ENSRNOT00000040348.7
      Conserved Domains (3) summary
      COG1196
      Location:479 → 861
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:52 → 83
      ANK; ANK repeat [structural motif]
      cl39094
      Location:23 → 239
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      61273439..61411141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281524.1 → XP_063137594.1  ankycorbin isoform X1

      UniProtKB/Swiss-Prot
      Q5U312
      UniProtKB/TrEMBL
      A0A8I5ZN94

    2. XM_006232062.5 → XP_006232124.1  ankycorbin isoform X1

      See identical proteins and their annotated locations for XP_006232124.1

      UniProtKB/Swiss-Prot
      Q5U312
      UniProtKB/TrEMBL
      A0A8I5ZN94
      Conserved Domains (3) summary
      COG1196
      Location:479 → 861
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:52 → 83
      ANK; ANK repeat [structural motif]
      cl39094
      Location:23 → 239
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_063281525.1 → XP_063137595.1  ankycorbin isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZN94, A6KJS6

    4. XM_006232064.5 → XP_006232126.1  ankycorbin isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZN94
      Related
      ENSRNOP00000103933.1, ENSRNOT00000146327.1
      Conserved Domains (5) summary
      cd00204
      Location:81 → 205
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:123 → 215
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:52 → 83
      ANK; ANK repeat [structural motif]
      cl19219
      Location:530 → 603
      DUF342; Protein of unknown function (DUF342)
      cl21478
      Location:726 → 833
      ATP-synt_B; ATP synthase B/B' CF(0)

    5. XM_006232063.5 → XP_006232125.1  ankycorbin isoform X2

      See identical proteins and their annotated locations for XP_006232125.1

      UniProtKB/TrEMBL
      A0A8I5ZN94, A6KJS6
      Conserved Domains (6) summary
      cd00204
      Location:81 → 205
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05046
      Location:486 → 531
      Img2; Mitochondrial large subunit ribosomal protein (Img2)
      pfam12796
      Location:123 → 215
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:52 → 83
      ANK; ANK repeat [structural motif]
      cl19219
      Location:559 → 632
      DUF342; Protein of unknown function (DUF342)
      cl21478
      Location:755 → 862
      ATP-synt_B; ATP synthase B/B' CF(0)

    6. XM_006232060.5 → XP_006232122.1  ankycorbin isoform X1

      See identical proteins and their annotated locations for XP_006232122.1

      UniProtKB/Swiss-Prot
      Q5U312
      UniProtKB/TrEMBL
      A0A8I5ZN94
      Conserved Domains (3) summary
      COG1196
      Location:479 → 861
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:52 → 83
      ANK; ANK repeat [structural motif]
      cl39094
      Location:23 → 239
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_017590719.3 → XP_017446208.1  ankycorbin isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U312.2 GenPept UniProtKB/Swiss-Prot:Q5U312

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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