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    Aspg asparaginase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aspgprovided by RGD
    Official Full Name
    asparaginaseprovided by RGD
    Primary source
    RGD:708388
    See related
    EnsemblRapid:ENSRNOG00000012843 AllianceGenome:RGD:708388
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables acyltransferase activity, transferring groups other than amino-acyl groups; asparaginase activity; and carboxylic ester hydrolase activity. Involved in asparagine metabolic process and phospholipid metabolic process. Orthologous to human ASPG (asparaginase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 209.9), Kidney (RPKM 170.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aspg in Genome Data Viewer
    Location:
    6q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136997832..137017417)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131176727..131196268)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136682279..136701673)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tudor domain containing 9 Neighboring gene RD3 like Neighboring gene fibrillarin, pseudogene 3 Neighboring gene microRNA 3545 Neighboring gene microRNA 203 Neighboring gene kinesin family member 26A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the transacylase activity of rat liver 60-kDa lysophospholipase-transacylase. Acyl transfer from the sn-2 to the sn-1 position. Sugimoto H, et al. Biochim Biophys Acta, 1999 May 18. PMID 10320809
    2. Cloning and expression of cDNA encoding rat liver 60-kDa lysophospholipase containing an asparaginase-like region and ankyrin repeat. Sugimoto H, et al. J Biol Chem, 1998 May 15. PMID 9575212
    3. Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver. Sugimoto H, et al. J Biol Chem, 1994 Feb 25. PMID 8119970
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112599

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables asparaginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparaginase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables asparaginase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparaginase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asparagine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aspartate family amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    60 kDa lysophospholipase
    Names
    asparaginase homolog
    lysophospholipase
    lysophospholipase-transacylase
    NP_653351.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144750.2 → NP_653351.1  60 kDa lysophospholipase

      See identical proteins and their annotated locations for NP_653351.1

      Status: PROVISIONAL

      Source sequence(s)
      AB009372
      UniProtKB/Swiss-Prot
      O88202, Q4G088
      UniProtKB/TrEMBL
      A0A0G2JSM2, A6KBU8
      Related
      ENSRNOP00000017454.3, ENSRNOT00000017454.6
      Conserved Domains (3) summary
      PLN03192
      Location:381 → 550
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:430 → 461
      ANK; ANK repeat [structural motif]
      cl00216
      Location:15 → 361
      L-asparaginase_like; Bacterial L-asparaginases and related enzymes

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      136997832..137017417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005505443.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88202.1 GenPept UniProtKB/Swiss-Prot:O88202

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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