Adcy8 adenylate cyclase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcy8provided by RGD
Official Full Name: adenylate cyclase 8provided by RGD
Primary source: RGD:2036
See related: EnsemblRapid:ENSRNOG00000004890 AllianceGenome:RGD:2036
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ac8
Summary: Enables several functions, including calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding activity; and protein dimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of protein kinase A activity; and cAMP biosynthetic process. Located in several cellular components, including caveola; clathrin-coated pit; and neuronal cell body membrane. Orthologous to human ADCY8 (adenylate cyclase 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 50.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q33

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (98306434..98555687, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (96417310..96665911, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (105353883..105593372, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction.
Title: Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction.
Data show that the IL-1beta-dependent transdifferentiation of VSMCs is associated with the de novo expression of a new family of AC8 isoforms. These isoforms are catalytically inactive with dominant-negative effects, decreasing total cAMP production. The inhibitory effect of AC8E on adenylyl cyclases (ACs) activity is accompanied by the formation of heterodimers between AC8E and functional ACs.
Title: Novel short isoforms of adenylyl cyclase as negative regulators of cAMP production.
Despite previous hints pointing to a major contribution of ACs, the presented data show that there is no apparent causality between AC activity and the occurrence of the epileptic phenotype.
Title: Adenylyl cyclases: expression in the developing rat thalamus and their role in absence epilepsy.
AC8 expression, besides being induced by the proinflammatory cytokine IL1beta, is also dependent on down-regulation of the Notch pathway occurring in an inflammatory context.
Title: The Notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation.
Mutation of the two critical cysteines results in exclusion of AKAP79 from lipid rafts and alterations in its membrane diffusion behavior and is accompanied by a loss of the ability of AKAP79 to regulate AC8.
Title: Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.
cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R.
Title: Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.
An IQ-like motif imparts calmodulin binding and autoinhibitory functions to adenylyl cyclcase 8.
Title: Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition.
Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.
Title: Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.
Integration of PGE2 signals depend on the upregulation of calcium/calmodulin stimulable adenylyl cyclase 8.
Title: PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8.

Submit: New GeneRIF Correction

General gene information

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Markers

AW060868 (e-PCR)
- UniSTS:180765

NoName (e-PCR)
- UniSTS:546632

Adcy8 (e-PCR), detects polymorphism
- UniSTS:546632

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables calcium- and calmodulin-responsive adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium- and calmodulin-responsive adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables calcium- and calmodulin-responsive adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 2A binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of protein kinase A activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to forskolin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucagon stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to morphine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to morphine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to morphine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to morphine	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glucose mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glucose mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in neuroinflammatory response	IEA Inferred from Electronic Annotation more info
involved_in neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in neuroinflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CREB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein complex oligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to stress	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylate cyclase type 8

Names: ATP pyrophosphate-lyase 8; adenylate cyclase 8 (brain); adenylate cyclase type VIII; adenylyl cyclase 8; ca(2+)/calmodulin-activated adenylyl cyclase; type VIII adenylyl cyclase

NP_058838.1

EC 4.6.1.1

XP_006241765.1

EC 4.6.1.1

XP_006241766.1

EC 4.6.1.1

XP_038934491.1

EC 4.6.1.1

XP_038934492.1

EC 4.6.1.1

XP_038934493.1

EC 4.6.1.1

XP_038934495.1

EC 4.6.1.1

XP_063119182.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017142.1 → NP_058838.1 adenylate cyclase type 8

See identical proteins and their annotated locations for NP_058838.1

Status: PROVISIONAL

Source sequence(s)

L26986

UniProtKB/Swiss-Prot

P40146

UniProtKB/TrEMBL

A6HRQ4, G3V6N0

Related

ENSRNOP00000006789.4, ENSRNOT00000006789.8

Conserved Domains (4) summary

smart00044
Location:363 → 561

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:970 → 1169

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:614 → 708

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:158 → 397

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

98306434..98555687 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078567.2 → XP_038934495.1 adenylate cyclase type 8 isoform X7

UniProtKB/TrEMBL

A0A2Z4LIN0

Conserved Domains (2) summary

pfam00211
Location:736 → 935

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:179 → 259

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_039078565.2 → XP_038934493.1 adenylate cyclase type 8 isoform X6

UniProtKB/TrEMBL

A0A2Z4LIN4

Conserved Domains (2) summary

pfam00211
Location:766 → 965

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:179 → 259

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_039078564.2 → XP_038934492.1 adenylate cyclase type 8 isoform X5

UniProtKB/TrEMBL

A0A2Z4LIN1

Conserved Domains (3) summary

pfam00211
Location:802 → 1001

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:179 → 259

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:476 → 570

DUF1053; Domain of Unknown Function (DUF1053)
XM_063263112.1 → XP_063119182.1 adenylate cyclase type 8 isoform X3

UniProtKB/TrEMBL

A6HRQ4, G3V6N0
XM_006241704.5 → XP_006241766.1 adenylate cyclase type 8 isoform X2

UniProtKB/TrEMBL

A0A8I6A3U3, A6HRQ4, G3V6N0

Related

ENSRNOP00000085627.1, ENSRNOT00000096414.2

Conserved Domains (4) summary

smart00044
Location:363 → 561

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:904 → 1103

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:614 → 636

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:158 → 397

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
XM_039078563.2 → XP_038934491.1 adenylate cyclase type 8 isoform X4

UniProtKB/TrEMBL

A0A2Z4LIM7

Conserved Domains (3) summary

pfam00211
Location:832 → 1031

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:179 → 259

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:476 → 570

DUF1053; Domain of Unknown Function (DUF1053)
XM_006241703.5 → XP_006241765.1 adenylate cyclase type 8 isoform X1

UniProtKB/TrEMBL

A0A8I6GDK4, A6HRQ4, G3V6N0

Related

ENSRNOP00000086009.1, ENSRNOT00000098906.2

Conserved Domains (4) summary

smart00044
Location:363 → 561

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:940 → 1139

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:614 → 708

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:158 → 397

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region