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    Rad52 RAD52 homolog, DNA repair protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rad52provided by RGD
    Official Full Name
    RAD52 homolog, DNA repair proteinprovided by RGD
    Primary source
    RGD:1304975
    See related
    EnsemblRapid:ENSRNOG00000009742 AllianceGenome:RGD:1304975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; double-strand break repair via single-strand annealing; and mitotic recombination. Predicted to act upstream of or within DNA double-strand break processing involved in repair via single-strand annealing; cellular response to oxidative stress; and regulation of nucleotide-excision repair. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung cancer (multiple); mucoepidermoid carcinoma; and nicotine dependence. Orthologous to human RAD52 (RAD52 homolog, DNA repair protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 40.2), Thymus (RPKM 36.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad52 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (154778320..154802002)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (153106062..153128598)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (152429826..152451875)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene uncharacterized LOC120102377 Neighboring gene COMM domain containing 6-like Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene ribosomal protein S12 like 11 Neighboring gene ninjurin 2 Neighboring gene ribosomal protein L4, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evaluating the role of RAD52 and its interactors as novel potential molecular targets for hepatocellular carcinoma. Li P, et al. Cancer Cell Int, 2019. PMID 31719794, Free PMC Article
    2. RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. Welty S, et al. J Biol Chem, 2018 Jan 26. PMID 29217771, Free PMC Article
    3. [Genetic variation in DNA repair gene RAD52 is associated with the response to platinum-based chemotherapy in SCLC patients]. Li HM, et al. Zhonghua Zhong Liu Za Zhi, 2016 Jul. PMID 27531263
    4. Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. Kazma R, et al. Carcinogenesis, 2012 May. PMID 22382497, Free PMC Article
    5. Identification of an SCLC susceptibility rs7963551 genetic polymorphism in a previously GWAS-identified 12p13.33 RAD52 lung cancer risk locus in the Chinese population. Han S, et al. Int J Clin Exp Med, 2015. PMID 26629180, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA double-strand break processing involved in repair via single-strand annealing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA double-strand break processing involved in repair via single-strand annealing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA recombinase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via single-strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein RAD52 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354109.1 → NP_001341038.1  DNA repair protein RAD52 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      154778320..154802002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763232.4 → XP_008761454.1  DNA repair protein RAD52 homolog isoform X1

      See identical proteins and their annotated locations for XP_008761454.1

      UniProtKB/TrEMBL
      D3ZZL1
      Related
      ENSRNOP00000013070.7, ENSRNOT00000013070.10
      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    2. XM_008763237.4 → XP_008761459.1  DNA repair protein RAD52 homolog isoform X9

      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    3. XM_039107433.2 → XP_038963361.1  DNA repair protein RAD52 homolog isoform X3

      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    4. XM_039107434.2 → XP_038963362.1  DNA repair protein RAD52 homolog isoform X7

      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    5. XM_063285895.1 → XP_063141965.1  DNA repair protein RAD52 homolog isoform X10

    6. XM_008763238.4 → XP_008761460.1  DNA repair protein RAD52 homolog isoform X11

      Related
      ENSRNOP00000073295.3, ENSRNOT00000084520.3
      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    7. XM_063285896.1 → XP_063141966.1  DNA repair protein RAD52 homolog isoform X12

      UniProtKB/TrEMBL
      A0A0G2K552

    8. XM_008763234.4 → XP_008761456.1  DNA repair protein RAD52 homolog isoform X2

      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    9. XM_063285893.1 → XP_063141963.1  DNA repair protein RAD52 homolog isoform X6

    10. XM_063285894.1 → XP_063141964.1  DNA repair protein RAD52 homolog isoform X8

    11. XM_017592585.3 → XP_017448074.1  DNA repair protein RAD52 homolog isoform X14

    12. XM_063285899.1 → XP_063141969.1  DNA repair protein RAD52 homolog isoform X15

    13. XM_063285901.1 → XP_063141971.1  DNA repair protein RAD52 homolog isoform X17

    14. XM_063285900.1 → XP_063141970.1  DNA repair protein RAD52 homolog isoform X16

    15. XM_008763235.4 → XP_008761457.1  DNA repair protein RAD52 homolog isoform X4

      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    16. XM_008763233.4 → XP_008761455.1  DNA repair protein RAD52 homolog isoform X1

      See identical proteins and their annotated locations for XP_008761455.1

      UniProtKB/TrEMBL
      D3ZZL1
      Conserved Domains (1) summary
      TIGR00607
      Location:39 → 200
      rad52; recombination protein rad52

    17. XM_063285892.1 → XP_063141962.1  DNA repair protein RAD52 homolog isoform X5

    18. XM_063285897.1 → XP_063141967.1  DNA repair protein RAD52 homolog isoform X12

      UniProtKB/TrEMBL
      A0A0G2K552

    19. XM_063285898.1 → XP_063141968.1  DNA repair protein RAD52 homolog isoform X13

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106617.2: Suppressed sequence

      Description
      NM_001106617.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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