Eva1a eva-1 homolog A, regulator of programmed cell death [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Eva1aprovided by RGD
Full Name: eva-1 homolog A, regulator of programmed cell deathprovided by RGD
Primary source: RGD:1559797
See related: EnsemblRapid:ENSRNOG00000007118 AllianceGenome:RGD:1559797
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam176a; Tmem166; RGD1559797
Summary: Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Orthologous to human EVA1A (eva-1 homolog A, regulator of programmed cell death). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 81.3), Liver (RPKM 66.5) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (116151595..116200827)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (114593773..114643011)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (112714023..112823659)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study suggested that MEM166 induced autophagy and apoptosis may in fact play a significant role in the cell death process following MCAO injury and its mediation may be through the Bcl-2. By blocking the activity of TMEM166 using siRNA
Title: Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

D4Rat176 (e-PCR), detects polymorphism
- UniSTS:227736

D4Rat268 (e-PCR), detects polymorphism
- UniSTS:227811

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within TOR signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within connective tissue replacement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy reserve metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: protein eva-1 homolog A

Names: family with sequence similarity 176, member A; protein FAM176A; transmembrane protein 166

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109243.1 → NP_001102713.1 protein eva-1 homolog A

See identical proteins and their annotated locations for NP_001102713.1

Status: PROVISIONAL

Source sequence(s)

CH473957

UniProtKB/TrEMBL

A6IAH4, D4A3V0

Related

ENSRNOP00000009321.5, ENSRNOT00000009321.7

Conserved Domains (1) summary

pfam14851
Location:20 → 159

FAM176; FAM176 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

116151595..116200827

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108150.2 → XP_038964078.1 protein eva-1 homolog A isoform X3

Conserved Domains (1) summary

pfam14851
Location:1 → 98

FAM176; FAM176 family
XM_006236708.5 → XP_006236770.1 protein eva-1 homolog A isoform X1

See identical proteins and their annotated locations for XP_006236770.1

UniProtKB/TrEMBL

A6IAH4, D4A3V0

Conserved Domains (1) summary

pfam14851
Location:20 → 159

FAM176; FAM176 family
XM_039108149.2 → XP_038964077.1 protein eva-1 homolog A isoform X2

Conserved Domains (1) summary

pfam14851
Location:3 → 126

FAM176; FAM176 family