Rab3gap2 RAB3 GTPase activating non-catalytic protein subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab3gap2provided by RGD
Official Full Name: RAB3 GTPase activating non-catalytic protein subunit 2provided by RGD
Primary source: RGD:1311518
See related: EnsemblRapid:ENSRNOG00000002353 AllianceGenome:RGD:1311518
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311518
Summary: Enables enzyme regulator activity. Predicted to be involved in several processes, including establishment of protein localization to endoplasmic reticulum membrane; positive regulation of organelle organization; and positive regulation of protein lipidation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in autophagosome and presynaptic membrane. Human ortholog(s) of this gene implicated in Martsolf syndrome and Warburg micro syndrome 2. Orthologous to human RAB3GAP2 (RAB3 GTPase activating non-catalytic protein subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 204.9), Brain (RPKM 108.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (99288984..99362817)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (96757430..96828930)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (103157806..103229010)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130522 (e-PCR)
- UniSTS:213806

RH131609 (e-PCR)
- UniSTS:214892

BI277882 (e-PCR)
- UniSTS:243883

RH141729 (e-PCR)
- UniSTS:223722

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in establishment of protein localization to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization to endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endoplasmic reticulum tubular network organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endoplasmic reticulum tubular network organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein lipidation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein lipidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rab3 GTPase-activating protein non-catalytic subunit

Names: RAB3 GTPase activating protein subunit 2; RAB3-GAP150; rab3 GTPase-activating protein 150 kDa subunit; rab3-GAP p150; rab3-GAP regulatory subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040154.3 → NP_001035244.2 rab3 GTPase-activating protein non-catalytic subunit

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F1LMT8

Related

ENSRNOP00000038422.8, ENSRNOT00000034888.8

Conserved Domains (2) summary

pfam14655
Location:73 → 497

RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus

pfam14656
Location:779 → 1365

RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

99288984..99362817

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090580.2 → XP_038946508.1 rab3 GTPase-activating protein non-catalytic subunit isoform X1

UniProtKB/TrEMBL

F1LMT8

Conserved Domains (2) summary

pfam14655
Location:73 → 497

RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus

pfam14656
Location:779 → 1345

RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus
XM_008769837.4 → XP_008768059.1 rab3 GTPase-activating protein non-catalytic subunit isoform X2

UniProtKB/TrEMBL

F1LMT8

Conserved Domains (2) summary

pfam14655
Location:1 → 226

RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus

pfam14656
Location:508 → 1094

RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001008294.1: Suppressed sequence

Description

NM_001008294.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.