Pld4 phospholipase D family, member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pld4provided by RGD
Official Full Name: phospholipase D family, member 4provided by RGD
Primary source: RGD:1598308
See related: EnsemblRapid:ENSRNOG00000028566 AllianceGenome:RGD:1598308
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in hematopoietic progenitor cell differentiation; phagocytosis; and regulation of cytokine production involved in inflammatory response. Predicted to act upstream of or within establishment of localization in cell. Predicted to be located in early endosome and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; phagocytic vesicle; and trans-Golgi network membrane. Orthologous to human PLD4 (phospholipase D family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 228.3), Thymus (RPKM 75.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (137639948..137647462)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (131818860..131827457)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (137323713..137331231)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143811 (e-PCR)
- UniSTS:233057

RH132624 (e-PCR)
- UniSTS:215907

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA 5'-3' DNA exonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5'-3' exonuclease PLD4

Names: phospholipase D4

NP_001119760.1

EC 3.1.4.4

XP_038968522.2

EC 3.1.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126288.1 → NP_001119760.1 5'-3' exonuclease PLD4

See identical proteins and their annotated locations for NP_001119760.1

Status: PROVISIONAL

Source sequence(s)

CH474034

UniProtKB/TrEMBL

A6KBW2, B1WBV8, G3V904

Related

ENSRNOP00000107901.1, ENSRNOT00000122215.1

Conserved Domains (2) summary

PHA02820
Location:120 → 527

PHA02820; phospholipase-D-like protein; Provisional

cl15239
Location:328 → 515

PLDc_SF; Catalytic domain of phospholipase D superfamily proteins