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    Ppp1r13b protein phosphatase 1, regulatory subunit 13B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp1r13bprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 13Bprovided by RGD
    Primary source
    RGD:1304651
    See related
    EnsemblRapid:ENSRNOG00000012653 AllianceGenome:RGD:1304651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Located in perinuclear region of cytoplasm. Orthologous to human PPP1R13B (protein phosphatase 1 regulatory subunit 13B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 72.5), Lung (RPKM 72.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r13b in Genome Data Viewer
    Location:
    6q32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136711834..136785068, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130890682..130963845, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136397658..136469757, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene kinesin light chain 1 Neighboring gene uncharacterized LOC134479261 Neighboring gene X-ray repair cross complementing 3 Neighboring gene zinc finger FYVE-type containing 21 Neighboring gene UPF0235 protein C15orf40 homolog Neighboring gene atherin-like Neighboring gene uncharacterized LOC120103629 Neighboring gene uncharacterized LOC134479260

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. Wilson AM, et al. J Neurosci, 2013 Jan 30. PMID 23365256, Free PMC Article
    2. ASPP proteins specifically stimulate the apoptotic function of p53. Samuels-Lev Y, et al. Mol Cell, 2001 Oct. PMID 11684014
    3. Transcriptional regulation by p53. Beckerman R, et al. Cold Spring Harb Perspect Biol, 2010 Aug. PMID 20679336, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-stimulating of p53 protein 1
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 13B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395106.1 → NP_001382035.1  apoptosis-stimulating of p53 protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2KB61, A6KBU0, D4A6A8
      Conserved Domains (6) summary
      PHA03247
      Location:444 → 860
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:153 → 329
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:890 → 916
      ANK; ANK repeat [structural motif]
      cd17224
      Location:2 → 86
      RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
      pfam13637
      Location:921 → 972
      Ank_4; Ankyrin repeats (many copies)
      cl17036
      Location:1020 → 1076
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      136711834..136785068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112418.2 → XP_038968346.1  apoptosis-stimulating of p53 protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KBU0, D4A6A8
      Related
      ENSRNOP00000112003.1, ENSRNOT00000136774.1
      Conserved Domains (6) summary
      PHA03247
      Location:541 → 957
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:250 → 426
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:987 → 1013
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:987 → 1073
      Ank_2; Ankyrin repeats (3 copies)
      cl17036
      Location:1117 → 1173
      SH3; Src Homology 3 domain superfamily
      cl28922
      Location:101 → 183
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_039112417.2 → XP_038968345.1  apoptosis-stimulating of p53 protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KBU0, D4A6A8
      Conserved Domains (6) summary
      PHA03247
      Location:576 → 992
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:250 → 426
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:1022 → 1048
      ANK; ANK repeat [structural motif]
      cd17224
      Location:101 → 183
      RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
      pfam12796
      Location:1022 → 1108
      Ank_2; Ankyrin repeats (3 copies)
      cl17036
      Location:1152 → 1208
      SH3; Src Homology 3 domain superfamily

    3. XM_008764939.4 → XP_008763161.1  apoptosis-stimulating of p53 protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8S6, A6KBU0, D4A6A8
      Related
      ENSRNOP00000088786.1, ENSRNOT00000097238.2
      Conserved Domains (7) summary
      cd00204
      Location:919 → 1042
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07321
      Location:154 → 317
      YscO; Type III secretion protein YscO
      pfam12796
      Location:925 → 1011
      Ank_2; Ankyrin repeats (3 copies)
      pfam13863
      Location:153 → 247
      DUF4200; Domain of unknown function (DUF4200)
      sd00045
      Location:925 → 951
      ANK; ANK repeat [structural motif]
      cl09111
      Location:208 → 318
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl17036
      Location:1055 → 1111
      SH3; Src Homology 3 domain superfamily

    4. XM_006240634.5 → XP_006240696.1  apoptosis-stimulating of p53 protein 1 isoform X3

      UniProtKB/TrEMBL
      A6KBU0, D4A6A8
      Conserved Domains (7) summary
      cd00204
      Location:924 → 1047
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07321
      Location:159 → 322
      YscO; Type III secretion protein YscO
      pfam12796
      Location:930 → 1016
      Ank_2; Ankyrin repeats (3 copies)
      pfam13863
      Location:158 → 252
      DUF4200; Domain of unknown function (DUF4200)
      sd00045
      Location:930 → 956
      ANK; ANK repeat [structural motif]
      cl09111
      Location:213 → 323
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl17036
      Location:1060 → 1116
      SH3; Src Homology 3 domain superfamily

    5. XM_063262028.1 → XP_063118098.1  apoptosis-stimulating of p53 protein 1 isoform X5

      UniProtKB/TrEMBL
      A6KBU0, D4A6A8
      Related
      ENSRNOP00000075666.3, ENSRNOT00000082600.3

    6. XM_008764941.3 → XP_008763163.1  apoptosis-stimulating of p53 protein 1 isoform X6

      UniProtKB/TrEMBL
      A6KBU0, D4A6A8
      Conserved Domains (7) summary
      cd00204
      Location:859 → 982
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07321
      Location:94 → 257
      YscO; Type III secretion protein YscO
      pfam12796
      Location:865 → 951
      Ank_2; Ankyrin repeats (3 copies)
      pfam13863
      Location:93 → 187
      DUF4200; Domain of unknown function (DUF4200)
      sd00045
      Location:865 → 891
      ANK; ANK repeat [structural motif]
      cl09111
      Location:148 → 258
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl17036
      Location:995 → 1051
      SH3; Src Homology 3 domain superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108062.1: Suppressed sequence

      Description
      NM_001108062.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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