Podxl podocalyxin-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Podxlprovided by RGD
Official Full Name: podocalyxin-likeprovided by RGD
Primary source: RGD:621878
See related: EnsemblRapid:ENSRNOG00000012495 AllianceGenome:RGD:621878
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PC; PCLP-1; podocalyxin
Summary: Involved in negative regulation of cell adhesion and podocyte development. Located in apical plasma membrane; cell body; and slit diaphragm. Orthologous to human PODXL (podocalyxin like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 453.2), Lung (RPKM 207.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (61102434..61149131, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (60135124..60181829, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (58829049..58893353, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kidney injury molecule-1 and podocalyxin dysregulation in an arginine vasopressin induced rodent model of preeclampsia.
Title: Kidney injury molecule-1 and podocalyxin dysregulation in an arginine vasopressin induced rodent model of preeclampsia.
Both the overexpression of CTGF and the loss of podocalyxin reflect renal damage in spontaneously hypertensive rats. CTGF and PCX may be involved in the mechanisms of podocyte injury and apoptosis induced by hypertension
Title: The effect of connective tissue growth factor on renal fibrosis and podocyte injury in hypertensive rats.
The immunohistochemical expression of caveolin-1 and podocalyxin in lungs from rats challenged with a 2-kDa macrophage-activating lipopeptide (MALP-2) and Flt3L, was examined.
Title: Expression of caveolin-1 and podocalyxin in rat lungs challenged with 2-kDa macrophage-activating lipopeptide and Flt3L.
cortactin mediates interaction between podocalyxin and actin filaments in podocytes and that alteration of this interaction may play a role in the process of morphological change of podocytes.
Title: Cortactin interacts with podocalyxin and mediates morphological change of podocytes through its phosphorylation.
Report ubiquitous yet distinct expression of podocalyxin on vascular surfaces in normal and tumor tissues in the rat.
Title: Ubiquitous yet distinct expression of podocalyxin on vascular surfaces in normal and tumor tissues in the rat.
Podocalyxin might be associated with the malignant progression of astrocytic tumors, and be a useful prognostic marker for astrocytic tumors.
Title: Podocalyxin expression in malignant astrocytic tumors.
podocalyxin has a role in defining the structure of the podocyte basal surface
Title: Enhanced podocalyxin expression alters the structure of podocyte basal surface.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137316 (e-PCR)
- UniSTS:219404

RH144252 (e-PCR)
- UniSTS:233497

D4RAT132 (e-PCR)
- UniSTS:121955

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial tube formation	ISO Inferred from Sequence Orthology more info
involved_in epithelial tube formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular filtration	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in podocyte development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of microvillus assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
is_active_in microvillus membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
located_in slit diaphragm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: podocalyxin

Names: podocalyxin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.