Kcnj12 potassium inwardly-rectifying channel, subfamily J, member 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj12provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 12provided by RGD
Primary source: RGD:621660
See related: EnsemblRapid:ENSRNOG00000002303 AllianceGenome:RGD:621660
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IRK2; Kir2.1; Kir2.2
Summary: Enables PDZ domain binding activity. Predicted to be involved in potassium ion import across plasma membrane; protein homotetramerization; and regulation of monoatomic ion transmembrane transport. Located in T-tubule; dendrite; and neuronal cell body. Orthologous to several human genes including KCNJ12 (potassium inwardly rectifying channel subfamily J member 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 59.7), Kidney (RPKM 46.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (46196110..46245008)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (45696621..45745528)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (47282208..47343501)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report coupling of cardiac Kir2.1 and Kir2.2 subunits with the plasma membrane-bound AKAPs 15 and 79. Cardiac membrane-associated AKAPs are a functionally essential part of the regulatory cascade determining IK1 current function.
Title: Role of plasma membrane-associated AKAPs for the regulation of cardiac I(K1) current by protein kinase A.
Nav1.5 N-terminal domain binding to alpha1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels
Title: Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels.
Kir2 channels composed of Kir2.1-2.3 subunits are expressed in neuronal and glial cells in the DRG and spinal cord, contributing to sensory transduction and motor control.
Title: Neuronal and glial expression of inward rectifier potassium channel subunits Kir2.x in rat dorsal root ganglion and spinal cord.
Immunohistochemical analysis reveals the expression of Kir2.1, Kir2.2, and Kir2.3 within spontaneously bursting neurons that regulate the level of pacemaker activity within the developing superficial dorsal horn.
Title: Inward-rectifying potassium (Kir) channels regulate pacemaker activity in spinal nociceptive circuits during early life.
Rat brain endothelial cells express Kv1.3, Kir2.1 and Kir2.2 K+ channels, all of which participate in setting membrane potential and could mediate K+ secretion into the brain interstitial fluid.
Title: Kv1 and Kir2 potassium channels are expressed in rat brain endothelial cells.
Biophysical properties of K(IR) (comprised of K(IR)2.1 and 2.2 subunits) have a substantive role in enabling agonists to alter the electrical state of a multilayered artery.
Title: KIR channels function as electrical amplifiers in rat vascular smooth muscle.
Immunochemical staining verified that both pericytes and endothelial cells of descending vasa recta express K(IR)2.1, K(IR)2.2, and K(IR)2.3 subunits.
Title: Descending vasa recta endothelia express inward rectifier potassium channels.
Kir2.1-overexpressed neonatal rat ventricular myocytes showed increased I(K1) density, hyperpolarized resting membrane potential, and increased action potential upstroke velocity
Title: IK1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayers.
a complex composed of SAP97, CASK, Veli, and Mint1 associates with Kir2 channels via the C-terminal PDZ-binding motif. SAP97, Veli-1, or Veli-3 binds directly to the Kir2.2 C terminus and recruits CASK
Title: A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.
There was a strong correlation between the transcript levels of Kir2.1 and K+-induced relaxation.
Title: Contribution of Na+-K+ pump and KIR currents to extracellular pH-dependent changes of contractility in rat superior mesenteric artery.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-sensitive inward rectifier potassium channel 12

Names: IRK-2; inward rectifier K(+) channel Kir2.2; potassium channel, inwardly rectifying subfamily J member 12; potassium voltage-gated channel subfamily J member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053981.2 → NP_446433.2 ATP-sensitive inward rectifier potassium channel 12

See identical proteins and their annotated locations for NP_446433.2

Status: PROVISIONAL

Source sequence(s)

BC127487

UniProtKB/Swiss-Prot

P52188

UniProtKB/TrEMBL

Q6U7S0

Related

ENSRNOP00000054762.2, ENSRNOT00000057953.4

Conserved Domains (3) summary

pfam01007
Location:47 → 187

IRK; Inward rectifier potassium channel

pfam08466
Location:2 → 46

IRK_N; Inward rectifier potassium channel N-terminal

pfam17655
Location:194 → 366

IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

46196110..46245008

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085061.2 → XP_038940989.1 ATP-sensitive inward rectifier potassium channel 12 isoform X2

UniProtKB/Swiss-Prot

P52188

UniProtKB/TrEMBL

Q6U7S0

Related

ENSRNOP00000112387.1, ENSRNOT00000153931.1

Conserved Domains (3) summary

pfam01007
Location:47 → 187

IRK; Inward rectifier potassium channel

pfam08466
Location:2 → 46

IRK_N; Inward rectifier potassium channel N-terminal

pfam17655
Location:194 → 366

IRK_C; Inward rectifier potassium channel C-terminal domain
XM_017596964.3 → XP_017452453.1 ATP-sensitive inward rectifier potassium channel 12 isoform X1

UniProtKB/Swiss-Prot

P52188

UniProtKB/TrEMBL

A6HF69

Related

ENSRNOP00000103646.1, ENSRNOT00000142509.1

Conserved Domains (2) summary

pfam01007
Location:149 → 476

IRK; Inward rectifier potassium channel

pfam08466
Location:105 → 148

IRK_N; Inward rectifier potassium channel N-terminal