Abtb2 ankyrin repeat and BTB domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abtb2provided by RGD
Official Full Name: ankyrin repeat and BTB domain containing 2provided by RGD
Primary source: RGD:620724
See related: EnsemblRapid:ENSRNOG00000008510 AllianceGenome:RGD:620724
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cca3
Summary: Predicted to enable protein heterodimerization activity. Predicted to act upstream of or within cellular response to toxic substance. Orthologous to human ABTB2 (ankyrin repeat and BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 98.9), Heart (RPKM 67.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (110409672..110563488)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (89954726..90108549)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (93494706..93648750)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134100 (e-PCR)
- UniSTS:217382

RH131288 (e-PCR)
- UniSTS:214571

BM384314 (e-PCR)
- UniSTS:260936

D3Got47 (e-PCR)
- UniSTS:113364

AW539457 (e-PCR)
- UniSTS:178663

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to toxic substance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to toxic substance	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin repeat and BTB/POZ domain-containing protein 2

Names: ankyrin repeat and BTB (POZ) domain containing 2; confluent 3Y1 cell-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134403.2 → NP_599230.2 ankyrin repeat and BTB/POZ domain-containing protein 2

See identical proteins and their annotated locations for NP_599230.2

Status: VALIDATED

Source sequence(s)

AB000216, BQ203018, CB609664, CB714885, CV110237, DY545654

UniProtKB/TrEMBL

A0A0G2JUJ7, A6HNR8, A6HNR9

Related

ENSRNOP00000069124.1, ENSRNOT00000085760.3

Conserved Domains (8) summary

smart00225
Location:845 → 946

BTB; Broad-Complex, Tramtrack and Bric a brac

cd00204
Location:516 → 670

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14821
Location:946 → 990

SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:836 → 939

BTB; BTB/POZ domain

pfam12796
Location:526 → 633

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:498 → 542

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:522 → 565

ANK; ANK repeat [structural motif]

cl23907
Location:194 → 242

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...