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    LKP2 LOV KELCH protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816408, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LKP2
    Official Full Name
    LOV KELCH protein 2
    Primary source
    TAIR:AT2G18915
    Locus tag
    AT2G18915
    See related
    Araport:AT2G18915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADAGIO 2; ADO2; LOV KELCH protein 2
    Summary
    encodes a member of F-box proteins that includes two other proteins in Arabidopsis (ZTL and FKF1). These proteins contain a unique structure containing a PAS domain at their N-terminus, an F-box motif, and 6 kelch repeats at their C-terminus. Overexpression results in arrhythmic phenotypes for a number of circadian clock outputs in both constant light and constant darkness, long hypocotyls under multiple fluences of both red and blue light, and a loss of photoperiodic control of flowering time. Although this the expression of this gene itself is not regulated by circadian clock, it physically interacts with Dof transcription factors that are transcriptionally regulated by circadian rhythm. LKP2 interacts with Di19, CO/COL family proteins.
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    Genomic context

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    See LKP2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (8194512..8197483, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for LKP2 in the circadian clock of Arabidopsis. Schultz TF, et al. Plant Cell, 2001 Dec. PMID 11752379, Free PMC Article
    2. LOV KELCH PROTEIN2 and ZEITLUPE repress Arabidopsis photoperiodic flowering under non-inductive conditions, dependent on FLAVIN-BINDING KELCH REPEAT F-BOX1. Takase T, et al. Plant J, 2011 Aug. PMID 21518052
    3. Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins. Lee CM, et al. Plant Physiol, 2018 Jul. PMID 29794020, Free PMC Article
    4. Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms. Liu H, et al. Proc Natl Acad Sci U S A, 2013 Oct 22. PMID 24101505, Free PMC Article
    5. Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana. Más P, et al. Nature, 2003 Dec 4. PMID 14654842

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LKP2 role in the circadian clock and flowering.
      Title: Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins.
    2. Data indicate that although cryptochrome 2 physically interacts with CIB1 in response to blue light, ZEITLUPE and LOV KELCH PROTEIN 2 are required for the function and blue-light suppression of degradation of CIB1.
      Title: Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms.
    3. Both LKP2 and ZTL suppress early flowering, especially under short-day (noninductive) conditions, and that such suppression is dependent on FKF1.
      Title: LOV KELCH PROTEIN2 and ZEITLUPE repress Arabidopsis photoperiodic flowering under non-inductive conditions, dependent on FLAVIN-BINDING KELCH REPEAT F-BOX1.
    4. ZTL, FKF1, and LKP2 together regulate TOC1 and PRR5 degradation and are major contributors to determining the period of circadian oscillation and enhancing robustness.
      Title: F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression.
    5. LKP2, a nuclear protein, interacted not only with itself but also with other members of the family, LKP1 and FKF1.
      Title: Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_127448.2
    NM_179652.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    LOV KELCH protein 2
    NP_565444.2
    • LOV KELCH protein 2 (LKP2); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), PAC motif (InterPro:IPR001610), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Kelch repeat type 1 (InterPro:IPR006652), PAS fold (InterPro:IPR013767), PAS (InterPro:IPR000014), Kelch repeat type 2 (InterPro:IPR011498), Kelch-type beta propeller (InterPro:IPR015915); BEST Arabidopsis thaliana protein match is: Galactose oxidase/kelch repeat superfamily protein (TAIR:AT5G57360.1); Has 8615 Blast hits to 5462 proteins in 811 species: Archae - 85; Bacteria - 1957; Metazoa - 2226; Fungi - 909; Plants - 2075; Viruses - 0; Other Eukaryotes - 1363 (source: NCBI BLink).
    NP_849983.1
    • LOV KELCH protein 2 (LKP2); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), Kelch repeat type 1 (InterPro:IPR006652), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), PAS fold (InterPro:IPR013767), PAS (InterPro:IPR000014), Kelch repeat type 2 (InterPro:IPR011498), Kelch-type beta propeller (InterPro:IPR015915); BEST Arabidopsis thaliana protein match is: Galactose oxidase/kelch repeat superfamily protein (TAIR:AT5G57360.1); Has 9191 Blast hits to 6011 proteins in 849 species: Archae - 93; Bacteria - 2251; Metazoa - 2432; Fungi - 932; Plants - 2094; Viruses - 0; Other Eukaryotes - 1389 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8194512..8197483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179652.2 → NP_849983.1  LOV KELCH protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849983.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5X4Z7, Q8W420, Q9C5S6
      UniProtKB/TrEMBL
      A0A178VWE1, A0A5S9WZH2
      Conserved Domains (4) summary
      PLN02193
      Location:251 → 588
      PLN02193; nitrile-specifier protein
      PRK13558
      Location:43 → 151
      PRK13558; bacterio-opsin activator; Provisional
      sd00038
      Location:294 → 342
      Kelch; KELCH repeat [structural motif]
      pfam12937
      Location:198 → 243
      F-box-like

    2. NM_127448.2 → NP_565444.2  LOV KELCH protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565444.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VWE1, A0A5S9WZH2
      Conserved Domains (8) summary
      PLN02153
      Location:277 → 578
      PLN02153; epithiospecifier protein
      cd00130
      Location:43 → 143
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      sd00038
      Location:284 → 332
      Kelch; KELCH repeat [structural motif]
      pfam07646
      Location:505 → 551
      Kelch_2; Kelch motif
      pfam12937
      Location:188 → 235
      F-box-like; F-box-like
      pfam13415
      Location:293 → 342
      Kelch_3; Galactose oxidase, central domain
      pfam13418
      Location:441 → 488
      Kelch_4; Galactose oxidase, central domain
      pfam13426
      Location:44 → 143
      PAS_9; PAS domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W420.1

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